Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 2/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL4028071 | 0.85 | MEN1 (0.41) | PDPK1HTR2AMEN1KMT2ANOS1 | |
| Ammonia Solution, Strong SCHEMBL3952657 | 0.85 | MEN1 (0.41) | PDPK1HTR2AMEN1KMT2ANOS1 | |
| Hydrochloric Acid SCHEMBL5228466 | 0.82 | MEN1 (0.40) | HTR2AMEN1KMT2ASLC6A4NOS1 | |
| SCHEMBL2515078 | 0.80 | ALDH1A1 (0.41) | PDPK1MEN1KMT2A | |
| SCHEMBL3290310 | 0.77 | MEN1 (0.56) | HTR2AMEN1KMT2ANOS1NOS3 | |
| Acetamide SCHEMBL5985486 | 0.75 | POLB (0.39) | MEN1KMT2ANOS1NOS3NOS2 | |
| Urea SCHEMBL29139836 | 0.74 | ATM (0.42) | MEN1KMT2ANOS1NOS3NOS2 | |
| SCHEMBL25796871 | 0.72 | CA2 (0.38) | MEN1KMT2ANOS1NOS3NOS2 | |
| SCHEMBL11806253 | 0.72 | PNMT (0.47) | HTR2A | |
| SCHEMBL27053505 | 0.72 | CA2 (0.38) | MEN1KMT2ANOS1NOS3NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0646112-A4 | TERTIARY AND SECONDARY AMINES AS ALPHA-2 ANTAGONISTS AND SEROTONIN UPTAKE INHIBITORS. | ABBOTT LAB (US) | 1997-04-02 | — | — | EP | claimed |
| EP-0646112-A1 | TERTIARY AND SECONDARY AMINES AS ALPHA-2 ANTAGONISTS AND SEROTONIN UPTAKE INHIBITORS | ABBOTT LABORATORIES (US) | 1995-04-05 | — | — | EP | claimed |
| EP-0646112-A4 | TERTIARY AND SECONDARY AMINES AS ALPHA-2 ANTAGONISTS AND SEROTONIN UPTAKE INHIBITORS. | ABBOTT LAB (US) | 1997-04-02 | — | — | EP | disclosed |
| EP-0646112-A1 | TERTIARY AND SECONDARY AMINES AS ALPHA-2 ANTAGONISTS AND SEROTONIN UPTAKE INHIBITORS | ABBOTT LABORATORIES (US) | 1995-04-05 | — | — | EP | disclosed |