Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | P4HB | P07237 | 1/20 | 0.31 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL5987268 | 1.00 | NPSR1 (0.34) | NPSR1BLMLMNAPMP22GFER | |
| Fumaric Acid SCHEMBL5988615 | 0.80 | NPSR1 (0.34) | NPSR1BLMLMNAPMP22GFER | |
| Fumaric Acid SCHEMBL5988148 | 0.80 | NPSR1 (0.34) | NPSR1BLMLMNAPMP22GFER | |
| SCHEMBL5987266 | 0.80 | LMNA (0.32) | LMNA | |
| SCHEMBL5986612 | 0.75 | P4HB (0.32) | P4HB | |
| Oxalic Acid SCHEMBL5987258 | 0.75 | P4HB (0.32) | P4HB | |
| SCHEMBL5986973 | 0.72 | P4HB (0.33) | P4HB | |
| Hydrochloric Acid SCHEMBL5985527 | 0.71 | TRPA1 (0.33) | P4HB | |
| SCHEMBL5988125 | 0.70 | P4HB (0.33) | P4HB | |
| Fumaric Acid SCHEMBL5987201 | 0.70 | BLM (0.42) | NPSR1BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045545-B1 | Aminoalkylbenzofurans as serotonin (5-HT(2c)) agonists | ELI LILLY AND COMPANY (US) | 2006-05-16 | — | — | US | disclosed |