Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | ECE1 | P42892 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | CTSA | P10619 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30441936 | 0.80 | SMPD3 (0.50) | SMPD3ECE1SMN1; SMN2CTSAKDM4E | |
| SCHEMBL14951107 | 0.80 | SMPD3 (0.50) | SMPD3ECE1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL28120090 | 0.79 | KCNMA1 (0.53) | SMPD3PPARGECE1SMN1; SMN2CTSA | |
| SCHEMBL19304124 | 0.79 | ADRB2 (0.43) | PPARGPPARDLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL5989736 | 0.79 | THRA (0.46) | SMPD3PPARGPPARDSMN1; SMN2ADRB2 | |
| SCHEMBL24731506 | 0.79 | SMPD3 (0.49) | SMPD3PPARGECE1LMNAMAPK1 | |
| SCHEMBL8940769 | 0.77 | HTR7 (0.53) | PPARGPPARDLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL27316656 | 0.77 | CTSA (0.51) | SMPD3ECE1SMN1; SMN2CTSAALDH1A1 | |
| SCHEMBL3922359 | 0.76 | CASR (0.57) | LMNASMN1; SMN2CTSA | |
| SCHEMBL24988889 | 0.76 | ADRB2 (0.43) | PPARGPPARDLMNAMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060257987-A1 | Ppar modulators | ELI LILLY AND COMPANY | 2006-11-16 | — | — | US | disclosed |
| EP-1660428-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005019151-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-03-03 | — | — | WO | disclosed |