Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1954826 | 0.82 | SIGMAR1 (0.44) | SIGMAR1LMNACYP3A4TRPM8NPSR1 | |
| SCHEMBL7416227 | 0.82 | SIGMAR1 (0.37) | SIGMAR1LMNACYP3A4TRPM8NPSR1 | |
| SCHEMBL4798849 | 0.81 | NPSR1 (0.52) | CYP3A4TRPM8NPSR1HPGDMAPT | |
| SCHEMBL6809913 | 0.81 | SIGMAR1 (0.36) | SIGMAR1LMNACYP3A4TRPM8NPSR1 | |
| SCHEMBL6798279 | 0.78 | SIGMAR1 (0.49) | SIGMAR1CYP3A4KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL6037534 | 0.77 | HSD17B1 (0.36) | SIGMAR1LMNANPSR1HSD17B1HSD17B2 | |
| SCHEMBL27476794 | 0.77 | TRPM8 (0.38) | SIGMAR1LMNACYP3A4TRPM8NPSR1 | |
| SCHEMBL5994906 | 0.76 | SIGMAR1 (0.36) | SIGMAR1LMNACYP3A4TRPM8NPSR1 | |
| SCHEMBL5477921 | 0.76 | LMNA (0.45) | LMNANPSR1ESR1KDM4EMAPT | |
| SCHEMBL3892110 | 0.76 | TRPM8 (0.47) | LMNATRPM8HPGDSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0917462-B1 | CELL ADHESION INHIBITORS | BIOGEN IDEC INC (US) | 2006-09-13 | — | — | EP | disclosed |
| US-20060030553-A1 | Cell adhesion inhibitors | ZHENG ZHONGLI | 2006-02-09 | — | — | US | disclosed |
| US-6949534-B2 | Cell adhesion inhibitors | BIOGEN IDEC MA INC. (US) | 2005-09-27 | — | — | US | disclosed |
| US-20040053907-A1 | Cell adhesion inhibitors | BIOGEN, INC. A MASSACHUSETTS CORPORATION. | 2004-03-18 | — | — | US | disclosed |
| US-6686350-B1 | Cell adhesion inhibitors | BIOGEN, INC. | 2004-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040053907-A1 | Cell adhesion inhibitors | ICAM1, VCAM1, EPCAM | SIGMAR1 4304/4885LMNA 2271/4885CYP3A4 4841/4885 |
| US-20060030553-A1 | Cell adhesion inhibitors | ICAM1, VCAM1, EPCAM | SIGMAR1 4304/4885LMNA 2271/4885CYP3A4 4841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.