Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.41 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4628458 | 0.72 | USP2 (0.48) | LMNASMN1; SMN2EPHX2P2RX2P2RX7 | |
| SCHEMBL5997374 | 0.72 | HSD11B1 (0.44) | SIGMAR1LMNAHSD11B1SMN1; SMN2KMT2A | |
| SCHEMBL7619851 | 0.72 | SIGMAR1 (0.45) | SIGMAR1KMT2AMEN1 | |
| SCHEMBL12343955 | 0.69 | EPHX2 (0.58) | SIGMAR1KMT2AMEN1EPHX2 | |
| SCHEMBL14503277 | 0.65 | EPHX2 (0.67) | LMNASMN1; SMN2KMT2AMEN1EPHX2 | |
| Iodobenzene SCHEMBL28516977 | 0.65 | P2RX7 (0.50) | LMNAHSD11B1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4884967 | 0.64 | SIGMAR1 (0.36) | SIGMAR1 | |
| SCHEMBL11239549 | 0.64 | GRIK1 (0.50) | SIGMAR1LMNAKMT2AMEN1 | |
| SCHEMBL30487751 | 0.64 | ALDH1A1 (0.63) | SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3709896 | 0.64 | ALDH1A1 (0.63) | SMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7041702-B1 | Pharmaceutically active compounds and methods of use | SCION PHARMACEUTICALS, INC. (US) | 2006-05-09 | — | — | US | claimed |