Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HINT1 | P49773 | 7/20 | 0.55 |
| ▸ | GSK3A | P49840 | 2/20 | 0.51 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.51 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | PNP | P00491 | 1/20 | 0.47 |
| ▸ | NT5E | P21589 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TGM2 | P21980 | 1/20 | 0.45 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.44 |
| ▸ | KRAS | P01116 | 1/20 | 0.43 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9545419 | 0.86 | POLB (0.60) | HINT1GSK3ARPS6KA3MAPK14TAAR1 | |
| SCHEMBL784432 | 0.86 | HINT1 (0.75) | HINT1GSK3ARPS6KA3MAPK14TAAR1 | |
| SCHEMBL7254452 | 0.82 | TYMP (0.56) | HINT1GSK3ARPS6KA3MAPK14TAAR1 | |
| SCHEMBL7254450 | 0.82 | TYMP (0.56) | HINT1GSK3ARPS6KA3MAPK14TAAR1 | |
| SCHEMBL646778 | 0.82 | HINT1 (0.54) | HINT1GSK3ARPS6KA3MAPK14PNP | |
| SCHEMBL4370987 | 0.81 | HINT1 (0.55) | HINT1GSK3ARPS6KA3MAPK14PNP | |
| SCHEMBL13833321 | 0.80 | ADORA3 (0.53) | HINT1PNPNT5EPOLBTGM2 | |
| SCHEMBL9200583 | 0.80 | ADORA3 (0.53) | HINT1PNPNT5EPOLBTGM2 | |
| SCHEMBL12031117 | 0.80 | ADORA3 (0.53) | HINT1PNPNT5EPOLBTGM2 | |
| SCHEMBL18759056 | 0.80 | ADORA3 (0.53) | HINT1PNPNT5EPOLBTGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694842-A1 | RNA AMIDATES AND THIOAMIDATES FOR RNAI | Geron Corporation (US) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005047506-A1 | RNA AMIDATES AND THIOAMIDATES FOR RNAI | GERON CORPORATION (US) | 2005-05-26 | — | — | WO | disclosed |