Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 5/20 | 0.79 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.79 |
| ▸ | LMNA | P02545 | 3/20 | 0.79 |
| ▸ | DRD3 | P35462 | 3/20 | 0.79 |
| ▸ | HTR2A | P28223 | 2/20 | 0.79 |
| ▸ | HTR2B | P41595 | 2/20 | 0.79 |
| ▸ | BLM | P54132 | 2/20 | 0.79 |
| ▸ | CNR1 | P21554 | 1/20 | 0.79 |
| ▸ | APEX1 | P27695 | 1/20 | 0.79 |
| ▸ | PDE4A | P27815 | 1/20 | 0.79 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.79 |
| ▸ | DRD2 | P14416 | 2/20 | 0.78 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.78 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.78 |
| ▸ | CYP2J2 | P51589 | 5/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | NPC1 | O15118 | 1/20 | 0.72 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.72 |
| ▸ | GMNN | O75496 | 1/20 | 0.72 |
| ▸ | USP2 | O75604 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5999809 | 1.00 | HRH1 (0.79) | HRH1KCNH2LMNADRD3HTR2A | |
| SCHEMBL1968090 | 1.00 | HRH1 (0.79) | HRH1KCNH2LMNADRD3HTR2A | |
| Hydrochloric Acid SCHEMBL11365096 | 0.99 | HRH1 (0.79) | HRH1KCNH2LMNADRD3HTR2A | |
| Terfenadine SCHEMBL8187662 | 0.97 | LMNA (0.77) | HRH1KCNH2LMNADRD3HTR2A | |
| SCHEMBL11365553 | 0.95 | HRH1 (0.71) | HRH1KCNH2LMNADRD3HTR2A | |
| Hydrochloric Acid SCHEMBL11378292 | 0.94 | HRH1 (0.72) | HRH1KCNH2LMNADRD3HTR2A | |
| SCHEMBL5603264 | 0.91 | HRH1 (0.82) | HRH1KCNH2LMNADRD3HTR2A | |
| SCHEMBL1969969 | 0.91 | HRH1 (0.82) | HRH1KCNH2LMNADRD3HTR2A | |
| SCHEMBL5603765 | 0.91 | HRH1 (0.82) | HRH1KCNH2LMNADRD3HTR2A | |
| SCHEMBL27561918 | 0.90 | KCNH2 (0.69) | HRH1KCNH2LMNADRD3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060014793-A1 | Process and diastereomeric salts useful for the optical resolution of racemic alpha-(4-(1, 1-dimethylethyl) phenyl] -4- (hydroxydiphenylmethyl) -1-piperidinebutanol and derivative compounds | MERRELL PHARMACEUTICALS INC. (US) | 2006-01-19 | — | — | US | disclosed |
| US-20040186137-A1 | Process and diastereomeric salts useful for the optical resolution of racemic alpha-(4-(1,1-dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl)-1-piperidinebutanol and derivative compounds | MERRELL PHARMACEUTICALS INC. | 2004-09-23 | — | — | US | disclosed |
| US-20030078429-A1 | Process and diastereomeric salts useful for the optical resolution of racemic a-[4- (1,1-dimethylethy) phenyl) -4- (hydroxydipenylmethyl) -1-piperidinebutanol and derivative compounds | NAKAMURA MITSUO (JP) | 2003-04-24 | — | — | US | disclosed |
| EP-0759904-B1 | PROCESS AND DIASTEREOMERIC SALTS USEFUL FOR THE OPTICAL RESOLUTION OF RACEMIC 4-[4-[-4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINYL]-1-HYDROXYBUTYL]-ALPHA,ALPHA-DIMETHYLBENZENE ACETIC ACID. | MERRELL PHARMA INC (US) | 2000-07-05 | — | — | EP | disclosed |
| EP-0759904-A1 | PROCESS AND DIASTEREOMERIC SALTS USEFUL FOR THE OPTICAL RESOLUTION OF RACEMIC ALPHA-[4-(1,1-DIMETHYLETHYL)PHENYL]-4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINEBUTANOL AND DERIVATIVE COMPOUNDS | MERRELL PHARMACEUTICALS INC. (US) | 1997-03-05 | — | — | EP | disclosed |
| WO-1995031436-A1 | PROCESS AND DIASTEREOMERIC SALTS USEFUL FOR THE OPTICAL RESOLUTION OF RACEMIC α-[4-(1,1-DIMETHYLETHYL)PHENYL]-4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINEBUTANOL AND DERIVATIVE COMPOUNDS | MERRELL PHARMACEUTICALS INC. (US) | 1995-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060014793-A1 | Process and diastereomeric salts useful for the optical resolution of racemic alpha-(4-(1, 1-dimethylethyl) phenyl] -4- (hydroxydiphenylmethyl) -1-piperidinebutanol and derivative compounds | ARRB1, DHCR24, ADRB1 | HRH1 274/4885KCNH2 4089/4885LMNA 2259/4885 |
| US-20030078429-A1 | Process and diastereomeric salts useful for the optical resolution of racemic a-[4- (1,1-dimethylethy) phenyl) -4- (hydroxydipenylmethyl) -1-piperidinebutanol and derivative compounds | ARRB1, HTR4, HCAR1 | HRH1 465/4885KCNH2 4514/4885LMNA 3041/4885 |
| US-20040186137-A1 | Process and diastereomeric salts useful for the optical resolution of racemic alpha-(4-(1,1-dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl)-1-piperidinebutanol and derivative compounds | REN, DHCR24, HCAR1 | HRH1 267/4885KCNH2 4371/4885LMNA 2839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.