Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 8/20 | 0.53 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.53 |
| ▸ | HTR1A | P08908 | 12/20 | 0.50 |
| ▸ | HTR1B | P28222 | 12/20 | 0.50 |
| ▸ | HTR1D | P28221 | 12/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5999973 | 0.84 | HTR2A (0.66) | HTR2ASLC6A4KCNH2 | |
| SCHEMBL5999729 | 0.77 | AHR (0.49) | HTR2ATRPM8SLC6A4KCNH2 | |
| SCHEMBL6000303 | 0.76 | ADRB2 (0.51) | HTR2AHTR1DHTR6SLC6A4KCNH2 | |
| SCHEMBL2531643 | 0.75 | TRPM8 (0.70) | HTR2ATRPM8HTR1AHTR1BHTR1D | |
| SCHEMBL5998632 | 0.73 | NOS1 (0.51) | HTR2ATRPM8MAPTSLC6A4KCNH2 | |
| SCHEMBL4086846 | 0.72 | GPR84 (0.58) | HTR2ATRPM8CYP1A2SLC6A4 | |
| SCHEMBL2535214 | 0.71 | TRPM8 (0.78) | HTR2ATRPM8HTR1AHTR1BHTR1D | |
| SCHEMBL626030 | 0.71 | HTR2A (1.00) | HTR2ATRPM8HTR1AHTR1BHTR1D | |
| SCHEMBL30724496 | 0.71 | HTR2A (1.00) | HTR2ATRPM8HTR1AHTR1BHTR1D | |
| SCHEMBL1399242 | 0.70 | HTR2A (0.60) | HTR2ATRPM8HTR1AHTR1BHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060058361-A1 | Therapeutic diphenyl ether ligands | PFIZER INC | 2006-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060058361-A1 | Therapeutic diphenyl ether ligands | HTR2B, HTR2C, HTR3B | HTR2A 7/4885TRPM8 753/4885HTR1A 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.