Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 7/20 | 0.54 |
| ▸ | RAB9A | P51151 | 7/20 | 0.54 |
| ▸ | TP53 | P04637 | 4/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.50 |
| ▸ | RELA | Q04206 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21695725 | 0.85 | SMN1; SMN2 (0.69) | SMN1; SMN2ALDH1A1USP2HSD17B10NPC1 | |
| SCHEMBL5943378 | 0.84 | SMN1; SMN2 (0.62) | SMN1; SMN2ALDH1A1USP2HSD17B10NPC1 | |
| SCHEMBL8267163 | 0.83 | SMN1; SMN2 (0.88) | SMN1; SMN2ALDH1A1USP2HSD17B10NPC1 | |
| SCHEMBL8267156 | 0.79 | SMN1; SMN2 (0.72) | SMN1; SMN2ALDH1A1USP2HSD17B10NPC1 | |
| SCHEMBL4702351 | 0.79 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1USP2HSD17B10NPC1 | |
| SCHEMBL10192041 | 0.79 | SMN1; SMN2 (0.76) | SMN1; SMN2ALDH1A1USP2HSD17B10NPC1 | |
| SCHEMBL8267293 | 0.78 | SMN1; SMN2 (0.74) | SMN1; SMN2ALDH1A1USP2HSD17B10NPC1 | |
| SCHEMBL8266868 | 0.77 | RAB9A (0.77) | SMN1; SMN2ALDH1A1USP2HSD17B10NPC1 | |
| SCHEMBL11534377 | 0.77 | SMN1; SMN2 (0.77) | SMN1; SMN2ALDH1A1USP2HSD17B10NPC1 | |
| SCHEMBL8267173 | 0.75 | NPC1 (0.90) | SMN1; SMN2ALDH1A1USP2HSD17B10NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060247320-A1 | Compounds for inhibiting KSP kinesin activity | SCHERING CORPORATION | 2006-11-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060247320-A1 | Compounds for inhibiting KSP kinesin activity | KIFC1, KIF5B, KIF2C | SMN1; SMN2 2022/4885ALDH1A1 2371/4885USP2 2868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.