Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.39 |
| ▸ | RELA | Q04206 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2997661 | 0.75 | LMNA (0.34) | KMT2ARAB9AMEN1NPC1MAPT | |
| SCHEMBL4598425 | 0.73 | HPGD (0.37) | SMN1; SMN2KMT2ARAB9ACYP1A2CYP3A4 | |
| SCHEMBL4243384 | 0.70 | CA12 (0.55) | SMN1; SMN2KMT2ARAB9ACYP1A2CYP3A4 | |
| SCHEMBL168718 | 0.69 | ALDH1A1 (0.38) | SMN1; SMN2KMT2ARAB9ACYP1A2MEN1 | |
| SCHEMBL14775163 | 0.67 | — | — | |
| SCHEMBL15009520 | 0.65 | NPC1 (0.45) | SMN1; SMN2KMT2ARAB9AMEN1NPC1 | |
| SCHEMBL28995903 | 0.63 | ALDH1A1 (0.33) | HPGDALDH1A1L3MBTL1LMNAKDM4E | |
| SCHEMBL16193564 | 0.63 | — | — | |
| SCHEMBL8547704 | 0.63 | HCAR3 (0.41) | SMN1; SMN2KMT2ARAB9AMEN1MAPT | |
| SCHEMBL15067892 | 0.63 | TSHR (0.41) | SMN1; SMN2KMT2AMEN1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1926143-A | Tricyclic benzazepine * derivatives as squalene synthase inhibitors for the treatment of cardiovascular diseases | BAYER HEALTHCARE AG (DE) | 2007-03-07 | — | — | CN | disclosed |
| EP-1706413-A1 | TRICYCLIC BENZAZEPINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS USED FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | Bayer HealthCare AG (DE) | 2006-10-04 | — | — | EP | disclosed |
| WO-2005068472-A1 | TRICYCLIC BENZAZEPINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS USED FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | BAYER HEALTHCARE AG (DE) | 2005-07-28 | — | — | WO | disclosed |