Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | COMT | P21964 | 4/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GCGR | P47871 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6003294 | 0.78 | ATP4A (0.43) | COMTKDM4ENPC1ALDH1A1LMNA | |
| SCHEMBL5547301 | 0.76 | ALOX5 (0.46) | ALOX5COMTPTGS1PTGS2KDM4E | |
| SCHEMBL10242340 | 0.74 | ALOX5 (0.58) | ALOX5COMTPTGS1PTGS2KDM4E | |
| SCHEMBL10242344 | 0.72 | ALOX5 (0.51) | ALOX5COMTPTGS1PTGS2KDM4E | |
| SCHEMBL27629514 | 0.71 | ALOX5 (0.50) | ALOX5COMTPTGS1PTGS2KDM4E | |
| SCHEMBL2093674 | 0.69 | ALOX5 (0.56) | ALOX5COMTPTGS1PTGS2NPC1 | |
| SCHEMBL2090158 | 0.68 | ALOX5 (0.50) | ALOX5COMTPTGS1PTGS2KDM4E | |
| SCHEMBL6003969 | 0.68 | ADORA3 (0.34) | GCGRTSHRNR1H3 | |
| SCHEMBL10242337 | 0.67 | ALOX5 (0.58) | ALOX5COMTPTGS1PTGS2NPC1 | |
| SCHEMBL5167355 | 0.67 | CYP17A1 (0.49) | ALOX5PTGS2KDM4ESMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042542-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-05-12 | — | — | WO | disclosed |