Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ELANE | P08246 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17065833 | 0.79 | HPGD (0.44) | PRKDCHPGDELANELMNAPOLB | |
| SCHEMBL24988962 | 0.78 | ERN1 (0.44) | PRKDCHPGDELANELMNAPOLB | |
| SCHEMBL9255869 | 0.76 | PRKDC (0.41) | PRKDCHPGDLMNAPOLBMEN1 | |
| SCHEMBL6002477 | 0.75 | PRKDC (0.46) | PRKDCHPGDMEN1KMT2AGAA | |
| SCHEMBL9257801 | 0.72 | KDM4E (0.39) | PRKDCHPGDLMNAMEN1KMT2A | |
| SCHEMBL3080094 | 0.69 | NCF1 (0.67) | HPGDLMNAMEN1KMT2AGAA | |
| SCHEMBL7491687 | 0.69 | NCF1 (0.67) | HPGDLMNAMEN1KMT2AGAA | |
| Phenanthrene SCHEMBL3217793 | 0.68 | ALDH1A1 (0.80) | HPGDTSHRALDH1A1CYP1A2CYP3A4 | |
| Phenanthrene SCHEMBL7746919 | 0.68 | ALDH1A1 (0.80) | HPGDTSHRALDH1A1CYP1A2CYP3A4 | |
| Phenanthrene SCHEMBL28092590 | 0.68 | ALDH1A1 (0.80) | HPGDTSHRALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042542-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-05-12 | — | — | WO | disclosed |