SCHEMBL17065833

SCHEMBL17065833

Brc1ccc2ccccc2c1N1CCCCC1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.44
PRKDC P78527 2/20 0.42
RAB9A P51151 2/20 0.42
NPC1 O15118 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2C19 P33261 1/20 0.42
HTT P42858 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
NCEH1 Q6PIU2 1/20 0.42
CRHBP P24387 1/20 0.41
CRHR2 Q13324 1/20 0.41
KDM4E B2RXH2 2/20 0.40
ATM Q13315 2/20 0.40
L3MBTL1 Q9Y468 2/20 0.40
MAPK1 P28482 1/20 0.40
CTDSP1 Q9GZU7 1/20 0.40
RXFP1 Q9HBX9 1/20 0.40
SIGMAR1 Q99720 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17065812 0.83 PRKDC (0.46) PRKDCKDM4EL3MBTL1ELANELMNA
SCHEMBL6002813 0.79 PRKDC (0.46) HPGDPRKDCRAB9ANPC1CYP1A2
SCHEMBL4877798 0.76 HPGD (0.44) HPGDPRKDCSMN1; SMN2KDM4EATM
SCHEMBL24988962 0.75 ERN1 (0.44) HPGDPRKDCKDM4EATML3MBTL1
SCHEMBL17065822 0.73 ACHE (0.47) RAB9ACYP1A2KDM4EATML3MBTL1
SCHEMBL29139355 0.73 RAB9A (0.47) HPGDPRKDCRAB9ANPC1CYP1A2
SCHEMBL9257801 0.72 KDM4E (0.39) HPGDPRKDCHTTKDM4EATM
SCHEMBL9255869 0.72 PRKDC (0.41) HPGDPRKDCHTTCRHBPCRHR2
SCHEMBL3602624 0.70 HTR6 (0.69) HPGDPRKDCHTTSMN1; SMN2KDM4E
SCHEMBL17065823 0.70 NPSR1 (0.44) HPGDRAB9ANPC1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3113768-A1 USE OF ARYLALKANOLAMINES AS SIGMA-1 RECEPTOR ANTAGONISTS Universita' Degli Studi Di Pavia (IT) 2017-01-11 EP disclosed
WO-2015132733-A1 USE OF ARYLALKANOLAMINES AS SIGMA-1 RECEPTOR ANTAGONISTS UNIVERSITA' DEGLI STUDI DI PAVIA (IT) 2015-09-11 WO disclosed