Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | PTGIR | P43119 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2091261 | 0.82 | DDB1 (0.40) | ESR1MAPTPOLBALDH1A1L3MBTL1 | |
| SCHEMBL6002450 | 0.73 | PTGIR (0.39) | CES2CES1PTGIRTDP1KMT2A | |
| SCHEMBL6973345 | 0.72 | CES2 (0.41) | CES2CES1ESR1MAPTALDH1A1 | |
| SCHEMBL3349691 | 0.72 | TDP1 (0.42) | CES2CES1MAPTALDH1A1TDP1 | |
| SCHEMBL28248518 | 0.71 | ALDH1A1 (0.47) | CES2CES1ESR1MAPTALDH1A1 | |
| SCHEMBL27662352 | 0.71 | L3MBTL1 (0.45) | CES2CES1ESR1MAPTALDH1A1 | |
| SCHEMBL2095839 | 0.70 | SCN9A (0.41) | CES2CES1POLBALDH1A1TDP1 | |
| SCHEMBL2095086 | 0.66 | PTGIR (0.55) | PTGIRTDP1L3MBTL1 | |
| SCHEMBL2093891 | 0.66 | CHRNB2 (0.36) | MAPTALDH1A1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL1396190 | 0.66 | TSHR (0.41) | ESR1POLBALDH1A1L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042542-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-05-12 | — | — | WO | disclosed |