Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28587764 | 0.83 | ALDH1A1 (0.41) | CES2CES1ALDH1A1NPC1RAB9A | |
| SCHEMBL665305 | 0.83 | ALDH1A1 (0.45) | CES2CES1ALDH1A1POLBTSHR | |
| SCHEMBL29524083 | 0.81 | GAA (0.41) | CES2CES1ALDH1A1POLBTSHR | |
| SCHEMBL3157322 | 0.81 | GAA (0.41) | CES2CES1ALDH1A1POLBTSHR | |
| SCHEMBL4199099 | 0.81 | CES2 (0.40) | CES2CES1ALDH1A1NPC1RAB9A | |
| Bicarbonate SCHEMBL29118429 | 0.80 | ALDH1A1 (0.46) | CES2CES1ALDH1A1POLBTSHR | |
| SCHEMBL465872 | 0.78 | POLB (0.40) | CES2CES1ALDH1A1NPC1RAB9A | |
| SCHEMBL2097563 | 0.77 | GPBAR1 (0.47) | CES2CES1ALDH1A1POLBTSHR | |
| SCHEMBL28749055 | 0.76 | MEN1 (0.41) | CES2CES1ALDH1A1NPC1RAB9A | |
| SCHEMBL11502164 | 0.76 | BCL2A1 (0.40) | CES2CES1ALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042542-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-05-12 | — | — | WO | disclosed |
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |