Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.59 |
| ▸ | NPC1 | O15118 | 5/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | CRHBP | P24387 | 1/20 | 0.59 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | NAMPT | P43490 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7565510 | 0.89 | RAB9A (0.71) | RAB9ANPC1HPGDCRHBPCRHR2 | |
| SCHEMBL10941324 | 0.86 | NAMPT (0.69) | RAB9ANPC1HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL10668920 | 0.86 | RAB9A (0.64) | RAB9ANPC1HPGDCRHBPCRHR2 | |
| SCHEMBL2228878 | 0.85 | MEN1 (0.54) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL19390510 | 0.85 | SMN1; SMN2 (0.67) | RAB9ANPC1HPGDCRHBPCRHR2 | |
| SCHEMBL15127704 | 0.84 | RAB9A (0.58) | RAB9ANPC1HPGDCRHBPCRHR2 | |
| SCHEMBL25845708 | 0.84 | SMN1; SMN2 (0.77) | RAB9ANPC1HPGDCRHBPCRHR2 | |
| SCHEMBL5636399 | 0.84 | RAB9A (0.72) | RAB9ANPC1HPGDCRHBPCRHR2 | |
| SCHEMBL4129868 | 0.84 | RAB9A (0.58) | RAB9ANPC1HPGDCRHBPCRHR2 | |
| SCHEMBL29893174 | 0.83 | RAB9A (0.76) | RAB9ANPC1HPGDSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11220513-B2 | Chromium-mediated coupling and application to the synthesis of halichondrins | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2022-01-11 | — | — | US | disclosed |
| US-11155562-B2 | Synthesis of halichondrin analogs and uses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2021-10-26 | — | — | US | disclosed |
| US-20210009605-A1 | CHROMIUM-MEDIATED COUPLING AND APPLICATION TO THE SYNTHESIS OF HALICHONDRINS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2021-01-14 | — | — | US | disclosed |
| US-20200223863-A1 | SYNTHESIS OF HALICHONDRIN ANALOGS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2020-07-16 | — | — | US | disclosed |
| US-10633392-B2 | Chromium-mediated coupling and application to the synthesis of halichondrins | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2020-04-28 | — | — | US | disclosed |
| US-10556910-B2 | Synthesis of halichondrin analogs and uses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2020-02-11 | — | — | US | disclosed |
| US-20200031843-A1 | CHROMIUM-MEDIATED COUPLING AND APPLICATION TO THE SYNTHESIS OF HALICHONDRINS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2020-01-30 | — | — | US | disclosed |
| US-10344038-B2 | Chromium-mediated coupling and application to the synthesis of halichondrins | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-07-09 | — | — | US | disclosed |
| US-20170137437-A1 | SYNTHESIS OF HALICHONDRIN ANALOGS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-05-18 | — | — | US | disclosed |
| EP-3160970-A1 | SYNTHESIS OF HALICHONDRIN ANALOGS AND USES THEREOF | President and Fellows of Harvard College (US) | 2017-05-03 | — | — | EP | disclosed |
| WO-2007037539-A1 | CELLULOSE DERIVATIVE FILM, OPTICAL COMPENSATION FILM, POLARIZING PLATE, AND LIQUID CRYSTAL DEVICE | FUJIFILM CORPORATION (JP) | 2007-04-05 | — | — | WO | disclosed |
| WO-2007023990-A1 | LIQUID CRYSTAL DISPLAY DEVICE | FUJI FILM CORPORATION (JP) | 2007-03-01 | — | — | WO | disclosed |
| US-20060167087-A1 | Substituted aniline derivatives | H. LUNDBECK A/S (DK) | 2006-07-27 | — | — | US | disclosed |
| EP-1606247-A1 | SUBSTITUTED ANILINE DERIVATIVES | H. Lundbeck A/S (DK) | 2005-12-21 | — | — | EP | disclosed |
| WO-2004080950-A1 | SUBSTITUTED ANILINE DERIVATIVES | H. LUNDBECK A/S (DK) | 2004-09-23 | — | — | WO | disclosed |
| US-4487713-A | HEAT TREATMENT WITH TITANIUM, TIN, ANTIMONY OR ZIRCONIUM COMPOUND | EXXON RESEARCH & ENGINEERING CO. (US) | 1984-12-11 | — | — | US | disclosed |
| US-4081472-A | CATALYTIC, FROM A CARBAMATE | MITSUI TOATSU CHEMICALS INC. (JA) | 1978-03-28 | — | — | US | disclosed |
| US-4069240-A | GROUP 8 METAL CATALYST | UNIROYAL, INC. (US) | 1978-01-17 | — | — | US | disclosed |
| US-4010191-A | Acyl derivatives of substituted bis-arylalkylamino compounds | DEUTSCHE GOLD- UND SILBER-SCHEIDEANSTALT VORMALS ROESSLER (DT) | 1977-03-01 | — | — | US | disclosed |
| US-3962302-A | Production of isocyanates from esters of carbamic acids (urethanes) | ATLANTIC RICHFIELD COMPANY (US) | 1976-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170137437-A1 | SYNTHESIS OF HALICHONDRIN ANALOGS AND USES THEREOF | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, KIF5C, KIF23 | RAB9A 2252/4885NPC1 499/4885HPGD 1448/4885 |
| US-11220513-B2 | Chromium-mediated coupling and application to the synthesis of halichondrins | CROCC, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, KAT7 | RAB9A 4411/4885NPC1 1914/4885HPGD 1277/4885 |
| US-20200223863-A1 | SYNTHESIS OF HALICHONDRIN ANALOGS AND USES THEREOF | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, KIF5C, KIF23 | RAB9A 2252/4885NPC1 499/4885HPGD 1448/4885 |
| US-11155562-B2 | Synthesis of halichondrin analogs and uses thereof | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, KIF5C, KIF23 | RAB9A 2252/4885NPC1 499/4885HPGD 1448/4885 |
| US-10344038-B2 | Chromium-mediated coupling and application to the synthesis of halichondrins | CA9, CROCC, CHD9 | RAB9A 1788/4885NPC1 1646/4885HPGD 1496/4885 |
| US-20210009605-A1 | CHROMIUM-MEDIATED COUPLING AND APPLICATION TO THE SYNTHESIS OF HALICHONDRINS | CROCC, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, KAT7 | RAB9A 4411/4885NPC1 1914/4885HPGD 1277/4885 |
| US-10633392-B2 | Chromium-mediated coupling and application to the synthesis of halichondrins | CA9, CROCC, CHD9 | RAB9A 1788/4885NPC1 1646/4885HPGD 1496/4885 |
| US-20060167087-A1 | Substituted aniline derivatives | CYP3A43, UGT2B7, CYP3A7 | RAB9A 1478/4885NPC1 237/4885HPGD 1643/4885 |
| US-20200031843-A1 | CHROMIUM-MEDIATED COUPLING AND APPLICATION TO THE SYNTHESIS OF HALICHONDRINS | CROCC, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, KAT7 | RAB9A 4411/4885NPC1 1914/4885HPGD 1277/4885 |
| US-10556910-B2 | Synthesis of halichondrin analogs and uses thereof | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, KIF5C, KIF23 | RAB9A 2252/4885NPC1 499/4885HPGD 1448/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.