Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3486119 | 0.79 | CES1 (0.37) | NR1H3NR1H2MEN1CYP3A4CYP2C9 | |
| SCHEMBL6002568 | 0.69 | TACR1 (0.30) | — | |
| SCHEMBL6002270 | 0.68 | NPSR1 (0.38) | NR1H3NR1H2MEN1CYP3A4CYP2C9 | |
| SCHEMBL6792995 | 0.65 | MEN1 (0.37) | NR1H3NR1H2MEN1KMT2AALDH1A1 | |
| SCHEMBL2015505 | 0.63 | ALDH1A1 (0.39) | MEN1CYP3A4CYP2C9CYP2C19KMT2A | |
| SCHEMBL28816160 | 0.63 | ALDH1A1 (0.39) | MEN1CYP3A4CYP2C9CYP2C19KMT2A | |
| SCHEMBL12574813 | 0.63 | ALDH1A1 (0.38) | NR1H3NR1H2MEN1CYP3A4CYP2C9 | |
| SCHEMBL6790778 | 0.63 | NR1H2 (0.32) | NR1H3NR1H2ALDH1A1 | |
| SCHEMBL11871425 | 0.63 | MLYCD (0.37) | SMN1; SMN2NPSR1ALDH1A1ALOX15 | |
| SCHEMBL104821 | 0.62 | ALDH1A1 (0.42) | MEN1CYP3A4CYP2C9CYP2C19KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102532162-A | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMA CO LTD | 2012-07-04 | — | — | CN | disclosed |
| EP-1678185-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042542-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-05-12 | — | — | WO | disclosed |