SCHEMBL6003619

SCHEMBL6003619

Nc1n[nH]cc1-c1ccccc1-c1c[nH]nc1N

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDR P35968 2/20 0.38
MAP4K4 O95819 1/20 0.38
CSF1R P07333 1/20 0.38
FGFR1 P11362 1/20 0.38
PDGFRA P16234 1/20 0.38
LTK P29376 1/20 0.38
MAPK8 P45983 1/20 0.38
CSNK1A1 P48729 1/20 0.38
LIMK1 P53667 1/20 0.38
CDK5 Q00535 1/20 0.38
ACVR1 Q04771 1/20 0.38
TNK2 Q07912 1/20 0.38
AURKB Q96GD4 1/20 0.38
CLK4 Q9HAZ1 1/20 0.38
DYRK1B Q9Y463 1/20 0.38
KDM4E B2RXH2 5/20 0.38
GAA P10253 4/20 0.38
PDPK1 O15530 1/20 0.38
CYP3A4 P08684 1/20 0.38
ALDH1A1 P00352 5/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11745392 0.82 DHFR (0.46) KDRMAP4K4CSF1RFGFR1PDGFRA
SCHEMBL544598 0.81 MAP4K4 (0.48) KDRMAP4K4CSF1RFGFR1PDGFRA
SCHEMBL9173107 0.78 DHFR (0.42) KDRMAP4K4CSF1RFGFR1PDGFRA
SCHEMBL7861029 0.78 NUDT1 (0.49) GAAIDO1MAPK1FLT3
SCHEMBL16346784 0.76 KDR (0.44) KDRMAP4K4CSF1RFGFR1PDGFRA
SCHEMBL581598 0.76 NPC1 (0.39) MAP4K4MAPTNPC1KMT2AMEN1
SCHEMBL11067965 0.75 PTPRC (0.35) KDRMAP4K4CSF1RFGFR1MAPK8
SCHEMBL4182365 0.73 ALDH1A1 (0.42) KDM4EGAAPDPK1CYP3A4ALDH1A1
SCHEMBL2059662 0.73 NCF1 (0.50) CSNK1A1ACVR1AURKBKDM4EALDH1A1
SCHEMBL20730424 0.73 FGFR1 (0.40) FGFR1CYP3A4NPSR1KMT2ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7092608-B2 Polyimide optical materials, polyimide precursor solutions and optical waveguide elements KABUSHIKI KAISHA TOSHIBA (JP) 2006-08-15 US claimed
US-20060159413-A1 POLYIMIDE OPTICAL MATERIALS, POLYIMIDE PRECURSOR SOLUTIONS AND OPTICAL WAVEGUIDE ELEMENTS KABUSHIKI KAISHA TOSHIBA (JP) 2006-07-20 US claimed
US-7092608-B2 Polyimide optical materials, polyimide precursor solutions and optical waveguide elements KABUSHIKI KAISHA TOSHIBA (JP) 2006-08-15 US disclosed
US-7082244-B2 Polyimide optical materials, polyimide precursor solutions and optical waveguide elements KABUSHIKI KAISHA TOSHIBA (JP) 2006-07-25 US disclosed
US-20060159413-A1 POLYIMIDE OPTICAL MATERIALS, POLYIMIDE PRECURSOR SOLUTIONS AND OPTICAL WAVEGUIDE ELEMENTS KABUSHIKI KAISHA TOSHIBA (JP) 2006-07-20 US disclosed
US-20040197064-A1 Polyimide optical materials, polyimide precursor solutions and optical waveguide elements KABUSHIKI KAISHA TOSHIBA (JP) 2004-10-07 US disclosed