Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | LTK | P29376 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.48 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.48 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.48 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.48 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.45 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.45 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8993116 | 0.83 | LTA4H (0.45) | MAP4K4CSF1RFGFR1PDGFRALTK | |
| SCHEMBL7901581 | 0.83 | MAOA (0.37) | MAP4K4CSF1RFGFR1PDGFRALTK | |
| SCHEMBL3724188 | 0.82 | KDR (0.46) | LTKKDRLIMK1AURKBDYRK1B | |
| SCHEMBL6003619 | 0.81 | KDR (0.38) | MAP4K4CSF1RFGFR1PDGFRALTK | |
| SCHEMBL9173111 | 0.80 | PTGS2 (0.41) | MAP4K4CSF1RFGFR1PDGFRALTK | |
| SCHEMBL8993172 | 0.80 | ALDH1A1 (0.42) | MAP4K4CSF1RFGFR1PDGFRALTK | |
| SCHEMBL1925085 | 0.80 | IMPDH2 (0.43) | CDK5AURKBCLK4DYRK1BLMNA | |
| SCHEMBL218119 | 0.79 | ALOX15 (0.52) | KDRLMNAALDH1A1HSD17B10NPSR1 | |
| SCHEMBL9735461 | 0.78 | IKBKB (0.46) | MAP4K4ALDH1A1NPSR1TDO2KDM4E | |
| SCHEMBL17619924 | 0.78 | MAPK14 (0.49) | MAP4K4CSF1RFGFR1LTKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 174 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107556243-A | A kind of method based on WK reactions and VHA reaction synthesizing pyrazole class compounds | 中国地质大学（武汉） | 2018-01-09 | — | — | CN | claimed |
| US-8802608-B2 | Composition for cleaning and rust prevention and process for producing semiconductor element or display element | Mitsubishi Gas Chemical Comany, Inc. (JP) | 2014-08-12 | — | — | US | claimed |
| CN-101755324-B | Composition for cleaning and rust prevention and process for producing semiconductor element or display element | MITSUBISHI GAS CHEMICAL CO (JP) | 2011-10-12 | — | — | CN | claimed |
| US-20100197136-A1 | COMPOSITION FOR CLEANING AND RUST PREVENTION AND PROCESS FOR PRODUCING SEMICONDUCTOR ELEMENT OR DISPLAY ELEMENT | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2010-08-05 | — | — | US | claimed |
| CN-101755324-A | Composition for cleaning and rust prevention and process for producing semiconductor element or display element | MITSUBISHI GAS CHEMICAL CO (JP) | 2010-06-23 | — | — | CN | claimed |
| CN-101553489-A | 4-amino-3-arylamino-6-arylpyrazolo[3,4-d]pyrimidine derivatives, methods for their preparation and their use as antiviral agents | DRITTE PATENTPORTFOLIO BETEILI (DE) | 2009-10-07 | — | — | CN | claimed |
| US-4149005-A | Process for preparing 1-phenyl-3-aminopyrazoles | MONTEDISON S.P.A. (IT) | 1979-04-10 | — | — | US | claimed |
| US-20250186411-A1 | Methods of Treating Disorders Associated with Overactivation of IKKB | US GOV VETERANS AFFAIRS (US) | 2025-06-12 | — | — | US | disclosed |
| US-12006321-B2 | Substituted pyrazolo[1,5-a]pyrimidines as apelin receptor agonists | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-06-11 | — | — | US | disclosed |
| EP-3535242-B1 | DNA PRIMASE AND GYRASE INHIBITORS | B G NEGEV TECHNOLOGIES AND APPLICATIONS LTD AT BEN GURION UNIV (IL) | 2024-01-24 | — | — | EP | disclosed |
| US-20230037225-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINES AS APELIN RECEPTOR AGONISTS | Sanford Burnham Prebys Medical Discovery Institute | 2023-02-02 | — | — | US | disclosed |
| US-11345705-B2 | Substituted pyrazolo[1,5-a]pyrimidines as apelin receptor agonists | Sanford Burnham Prebys Medical Discovery Institute (US) | 2022-05-31 | — | — | US | disclosed |
| US-20210236466-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY | NOVARTIS PHARMA AG (CH) | 2021-08-05 | — | — | US | disclosed |
| US-4235995-A | BACTERIOCIDES, PARASITICIDES, HERBICIDES | ELI LILLY AND COMPANY (US) | 1980-11-25 | — | — | US | disclosed |
| EP-0015361-A1 | Cumarinic pigments, process for their preparation and their use | Montedison S.p.A. (IT) | 1980-09-17 | — | — | EP | disclosed |
| US-4169838-A | PYRAZOLYLTRIAZOLE HERBICIDES | AMERICAN CYANAMID COMPANY (US) | 1979-10-02 | — | — | US | disclosed |
| US-4145554-A | BACTERICIDES, MICROBIOCIDES, HERBICIDES, PARASITICDES | ELI LILLY AND COMPANY (US) | 1979-03-20 | — | — | US | disclosed |
| US-4115097-A | Pyrazolyltriazole herbicides | AMERICAN CYANAMID COMPANY (US) | 1978-09-19 | — | — | US | disclosed |
| US-4066776-A | Anti-bacterial compositions containing certain 3-nitropyrazoles | ELI LILLY AND COMPANY (US) | 1978-01-03 | — | — | US | disclosed |
| US-4021556-A | PYRAZOLO(1,5A) PYRIMIDINE DERIVATIVES | ICN PHARMACEUTICALS, INC. (US) | 1977-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11345705-B2 | Substituted pyrazolo[1,5-a]pyrimidines as apelin receptor agonists | APLNR, AP3B1, AGTR1 | MAP4K4 1723/4885CSF1R 759/4885FGFR1 115/4885 |
| US-20230037225-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINES AS APELIN RECEPTOR AGONISTS | APLNR, AP3B1, AGTR1 | MAP4K4 1723/4885CSF1R 759/4885FGFR1 115/4885 |
| US-12006321-B2 | Substituted pyrazolo[1,5-a]pyrimidines as apelin receptor agonists | APLNR, AP3B1, AGTR1 | MAP4K4 1723/4885CSF1R 759/4885FGFR1 115/4885 |
| US-20210236466-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY | STING1, CGAS, IRF3 | MAP4K4 1819/4885CSF1R 2707/4885FGFR1 2321/4885 |
| US-20250186411-A1 | Methods of Treating Disorders Associated with Overactivation of IKKB | NFKBIA, IKBKG, IKBKB | MAP4K4 547/4885CSF1R 3347/4885FGFR1 3750/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.