Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 3/20 | 0.64 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | CPT2 | P23786 | 1/20 | 0.42 |
| ▸ | CPT1A | P50416 | 1/20 | 0.42 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.42 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.41 |
| ▸ | CTSG | P08311 | 1/20 | 0.40 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4878508 | 0.84 | AKR1C3 (0.71) | AKR1C3AKR1C1ALOX15MEN1KMT2A | |
| SCHEMBL6004358 | 0.82 | AKR1C3 (0.47) | AKR1C3AKR1C1ALOX15MEN1KMT2A | |
| SCHEMBL9801780 | 0.74 | AKR1C3 (0.49) | AKR1C3AKR1C1ALOX15MEN1KMT2A | |
| SCHEMBL24620575 | 0.73 | ALOX15 (0.42) | AKR1C3AKR1C1ALOX15ALDH1A1 | |
| SCHEMBL29808214 | 0.73 | ALOX15 (0.42) | AKR1C3AKR1C1ALOX15ALDH1A1 | |
| SCHEMBL31587999 | 0.72 | POLB (0.58) | MEN1KMT2AALDH1A1PPP1CAPKM | |
| SCHEMBL6003811 | 0.70 | ALDH1A1 (0.65) | AKR1C3AKR1C1ALOX15MEN1KMT2A | |
| SCHEMBL22290631 | 0.69 | AKR1C3 (0.51) | AKR1C3AKR1C1ALOX15ALDH1A1MMP2 | |
| SCHEMBL5352054 | 0.69 | AKR1C3 (0.51) | AKR1C3AKR1C1ALOX15 | |
| SCHEMBL23012370 | 0.69 | AKR1C3 (0.52) | AKR1C3AKR1C1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060183780-A1 | Pyrazole compounds useful in the treatment of inflammation | BIOLIPOX AB (SE) | 2006-08-17 | — | — | US | disclosed |
| EP-1603897-A1 | PYRAZOLE COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATION | Biolipox AB (SE) | 2005-12-14 | — | — | EP | disclosed |
| WO-2004080999-A1 | PYRAZOLE COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATION | BIOLIPOX AB (SE) | 2004-09-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060183780-A1 | Pyrazole compounds useful in the treatment of inflammation | ALOX15, ALOX12, ALOX15B | AKR1C3 223/4885AKR1C1 512/4885ALOX15 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.