Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.51 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PRNP | P04156 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27685906 | 0.88 | KDM4E (0.55) | KDM4EALDH1A1POLBHPGDHSD17B10 | |
| SCHEMBL27773370 | 0.87 | KDM4E (0.50) | KDM4EALDH1A1POLBHPGDHSD17B10 | |
| SCHEMBL5717584 | 0.84 | GRM2 (0.55) | GRM2KDM4EALDH1A1POLBHPGD | |
| SCHEMBL281896 | 0.83 | MTNR1A (0.49) | KDM4EALDH1A1POLBHPGDHSD17B10 | |
| SCHEMBL16832417 | 0.83 | KDM4E (0.72) | GRM2KDM4EALDH1A1POLBHPGD | |
| SCHEMBL2652933 | 0.81 | CTSL (0.61) | KDM4EALDH1A1POLBHPGDHSD17B10 | |
| SCHEMBL9724191 | 0.81 | LMNA (0.58) | GRM2LMNA | |
| SCHEMBL16832328 | 0.81 | PLA2G2A (0.64) | GRM2KDM4EALDH1A1POLBHPGD | |
| SCHEMBL19610556 | 0.79 | PDE4B (0.52) | GRM2KDM4EALDH1A1POLBHPGD | |
| SCHEMBL5258916 | 0.79 | GRM2 (0.50) | GRM2KDM4EALDH1A1POLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |