Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.33 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3940018 | 0.81 | NR1H4 (0.42) | NPC1RAB9ASMN1; SMN2KMT2AGPBAR1 | |
| SCHEMBL4970805 | 0.80 | CYP17A1 (0.37) | NPC1RAB9ATP53KMT2A | |
| SCHEMBL314833 | 0.80 | BRD4 (0.47) | PTGS2PTGS1NPC1RAB9AKMT2A | |
| SCHEMBL27936742 | 0.79 | TP53 (0.41) | NPC1RAB9ASMN1; SMN2TP53ACHE | |
| SCHEMBL26977353 | 0.77 | MAPK14 (0.40) | PTGS2NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL8800725 | 0.74 | CYP17A1 (0.46) | PTGS2PTGS1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9936299 | 0.73 | HSD11B1 (0.36) | PTGS2PTGS1NPC1RAB9ATP53 | |
| SCHEMBL10404277 | 0.71 | KIF11 (0.35) | PTGS2NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL11593511 | 0.68 | PTGS1 (0.51) | PTGS2PTGS1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16404607 | 0.67 | BRD4 (0.66) | PTGS2PTGS1TP53LMNAGPR55 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2792360-A1 | (1aR,12bS)-8-cyclohexyl-11-fluoro-N-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,2b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide for use in treating HCV | IP Gesellschaft für Management mbH (DE) | 2014-10-22 | — | — | EP | disclosed |
| CN-103889971-A | Solid forms of (1, L-dioxo-4-thiomorpholinyl) - [6- [ [3 (4-fluorophenyl) -5-methyl-4-isoxazolyl ] methoxy ] -3-pyridine ] -methanone | HOFFMANN LA ROCHE | 2014-06-25 | — | — | CN | disclosed |
| EP-2451808-B1 | PYRIDAZINE COMPOUNDS FOR CONTROLLING INVERTEBRATE PESTS | BASF SE (DE) | 2014-03-26 | — | — | EP | disclosed |
| US-20060252807-A1 | Novel ortho-terphenyl inhibitors of p38 kinase and methods of treating inflammatory disorders | KALYPSYS, INC. | 2006-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252807-A1 | Novel ortho-terphenyl inhibitors of p38 kinase and methods of treating inflammatory disorders | MAPK1, MAP3K1, MAPK4 | PTGS2 1030/4885PTGS1 561/4885NPC1 1832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.