Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SI | P14410 | 1/20 | 0.40 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3646366 | 0.81 | TP53 (0.39) | TP53MGAMGAASIMGAM2 | |
| SCHEMBL11593511 | 0.80 | PTGS1 (0.51) | TP53MGAMGAASIMGAM2 | |
| SCHEMBL6004541 | 0.79 | PTGS2 (0.39) | TP53ACHEGPBAR1SMN1; SMN2NPC1 | |
| SCHEMBL314833 | 0.78 | BRD4 (0.47) | GAANPC1RAB9AL3MBTL1 | |
| SCHEMBL16720790 | 0.71 | GPBAR1 (0.50) | TP53GAAHTR7GPBAR1 | |
| SCHEMBL16404612 | 0.71 | BRD4 (0.62) | NPC1RAB9A | |
| SCHEMBL9936299 | 0.71 | HSD11B1 (0.36) | TP53GPBAR1NPC1RAB9A | |
| SCHEMBL24799555 | 0.69 | RPS6KB1 (0.52) | TP53MGAMGAASIMGAM2 | |
| SCHEMBL15219993 | 0.69 | NPC1 (0.47) | TP53NOTUMGRM5RPS6KB1SMN1; SMN2 | |
| SCHEMBL21752799 | 0.69 | GPBAR1 (0.48) | GAAHTR7GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103313982-A | Phenyl-isoxazole derivatives and process for the preparation thereof | IL YANG PHARM CO LTD | 2013-09-18 | — | — | CN | claimed |
| CN-103313982-A | Phenyl-isoxazole derivatives and process for the preparation thereof | IL YANG PHARM CO LTD | 2013-09-18 | — | — | CN | disclosed |