Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.53 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.52 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 3/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TOP1 | P11387 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.44 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1692394 | 0.81 | DHODH (0.44) | HDAC8KDM4EALDH1A1HPGD | |
| SCHEMBL14983473 | 0.80 | PIK3CG (0.55) | AURKADYRK1ACLK4PDE10AABCG2 | |
| SCHEMBL28317840 | 0.77 | AURKA (0.56) | AURKADYRK1ACLK4PDE10AABCG2 | |
| SCHEMBL6004865 | 0.77 | L3MBTL1 (0.54) | ABCG2KDM4EALDH1A1CYP19A1 | |
| SCHEMBL3892242 | 0.77 | COMT (0.43) | KDM4EALDH1A1HPGD | |
| SCHEMBL6004768 | 0.76 | KDM4E (0.51) | HDAC8KDM4EALDH1A1HPGD | |
| SCHEMBL6004734 | 0.74 | EGFR (0.51) | — | |
| SCHEMBL6004302 | 0.74 | KDM4E (0.43) | KDM4EALDH1A1HPGD | |
| SCHEMBL6004749 | 0.74 | CYP1A2 (0.41) | HDAC8KDM4EALDH1A1HPGD | |
| SCHEMBL6004845 | 0.74 | MAPK14 (0.52) | KDM4EALDH1A1HPGDTOP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |