Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | NMT1 | P30419 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004274 | 0.90 | TGFBR1 (0.48) | CYP3A4IP6K1MAOANMT1MEN1 | |
| SCHEMBL6004285 | 0.87 | CYP3A4 (0.46) | CYP3A4IP6K1MAOANMT1MEN1 | |
| SCHEMBL6002919 | 0.85 | SLC22A12 (0.38) | MAOAALDH1A1HSD17B10 | |
| SCHEMBL6004179 | 0.83 | CYP3A4 (0.44) | CYP3A4IP6K1NMT1PLAUPLAT | |
| SCHEMBL6004931 | 0.82 | TGFBR1 (0.48) | CYP3A4MAOAMEN1KMT2ADYRK1A | |
| SCHEMBL6005361 | 0.82 | TGFBR1 (0.38) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL6004204 | 0.81 | TGFBR1 (0.39) | — | |
| SCHEMBL6004827 | 0.77 | CYP3A4 (0.44) | CYP3A4IP6K1MAOANMT1MEN1 | |
| SCHEMBL6002895 | 0.77 | TGFBR1 (0.48) | MAOANPC1KDM4ECYP1A2CYP2C9 | |
| SCHEMBL3897482 | 0.76 | SRC (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |