Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 10/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | NMT1 | P30419 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | PLAT | P00750 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004931 | 0.92 | TGFBR1 (0.48) | TGFBR1CYP3A4MAOADYRK1AMEN1 | |
| SCHEMBL6004895 | 0.90 | CYP3A4 (0.45) | CYP3A4IP6K1MAOANMT1DYRK1A | |
| SCHEMBL6004827 | 0.87 | CYP3A4 (0.44) | TGFBR1CYP3A4IP6K1MAOANMT1 | |
| SCHEMBL6004185 | 0.87 | TGFBR1 (0.59) | TGFBR1MEN1KMT2AKDM4ENPC1 | |
| SCHEMBL6002895 | 0.86 | TGFBR1 (0.48) | TGFBR1MAOAKDM4ENPC1 | |
| SCHEMBL6002971 | 0.85 | ATM (0.49) | TGFBR1 | |
| SCHEMBL3893031 | 0.85 | ATM (0.49) | TGFBR1 | |
| SCHEMBL6004725 | 0.84 | TGFBR1 (0.48) | TGFBR1KDM4ENPC1 | |
| SCHEMBL6004710 | 0.84 | CYP3A4 (0.42) | CYP3A4IP6K1NMT1KDM4ENPC1 | |
| SCHEMBL6002965 | 0.84 | TGFBR1 (0.49) | TGFBR1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |