SCHEMBL6007444

SCHEMBL6007444

O=Cc1cccc2nc3ccccc3nc12

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NQO2 P16083 5/20 0.50
ALDH1A1 P00352 4/20 0.50
MAPT P10636 4/20 0.50
KMT2A Q03164 3/20 0.50
RAB9A P51151 3/20 0.50
GAA P10253 2/20 0.50
NPSR1 Q6W5P4 1/20 0.50
THRB P10828 3/20 0.48
BLM P54132 3/20 0.48
MEN1 O00255 2/20 0.48
LMNA P02545 1/20 0.48
TDP1 Q9NUW8 1/20 0.48
POLB P06746 1/20 0.41
CASP6 P55212 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
KDM4E B2RXH2 1/20 0.41
NPC1 O15118 1/20 0.41
MAPK1 P28482 1/20 0.41
ATM Q13315 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12086511 0.84 NQO2 (0.59) NQO2ALDH1A1MAPTKMT2ARAB9A
SCHEMBL28343024 0.81 ALDH1A1 (0.48) NQO2ALDH1A1MAPTKMT2ARAB9A
SCHEMBL5117247 0.80 MAPT (0.44) NQO2ALDH1A1MAPTKMT2ARAB9A
SCHEMBL7718133 0.80 TDP1 (0.46) NQO2ALDH1A1MAPTKMT2ANPSR1
SCHEMBL27533262 0.79 ALDH1A1 (0.42) NQO2ALDH1A1MAPTKMT2ARAB9A
SCHEMBL6007390 0.79 MAPT (0.50) NQO2ALDH1A1MAPTKMT2ARAB9A
SCHEMBL29149701 0.79 MAPT (0.50) NQO2ALDH1A1MAPTKMT2ARAB9A
SCHEMBL291535 0.79 NQO2 (0.50) NQO2ALDH1A1MAPTKMT2ARAB9A
SCHEMBL6644903 0.79 ALDH1A1 (0.50) NQO2ALDH1A1MAPTKMT2ARAB9A
SCHEMBL4654883 0.77 MAPT (0.69) NQO2ALDH1A1MAPTKMT2ARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110878087-B Shenqinmycin triazole derivative and preparation method and application thereof 长江大学 2021-04-09 CN claimed
CN-109134438-B 1-phenazinyl (phenyl) (5-pyrimidinyl) methanol compound and preparation method and application thereof 长江大学 2020-10-09 CN claimed
CN-110878087-A Shenqinmycin triazole derivative and preparation method and application thereof 长江大学 2020-03-13 CN claimed
CN-110878087-B Shenqinmycin triazole derivative and preparation method and application thereof 长江大学 2021-04-09 CN disclosed
CN-110878087-B Shenqinmycin triazole derivative and preparation method and application thereof 长江大学 2021-04-09 CN disclosed
US-10913936-B2 Phenazine degrading agents and related compositions, methods and systems for interfering with viability of bacteria CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2021-02-09 US disclosed
US-20210032603-A1 PHENAZINE DEGRADING AGENTS AND RELATED COMPOSITIONS, METHODS AND SYSTEMS FOR INTERFERING WITH VIABILITY OF BACTERIA CALIFORNIA INSTITUTE OF TECHNOLOGY 2021-02-04 US disclosed
CN-109134438-B 1-phenazinyl (phenyl) (5-pyrimidinyl) methanol compound and preparation method and application thereof 长江大学 2020-10-09 CN disclosed
CN-110878087-A Shenqinmycin triazole derivative and preparation method and application thereof 长江大学 2020-03-13 CN disclosed
CN-110878087-A Shenqinmycin triazole derivative and preparation method and application thereof 长江大学 2020-03-13 CN disclosed
CN-106957317-B Novel pyrazole derivatives 持田制药株式会社 2019-12-31 CN disclosed
US-5635395-A Optically active 1,4-dihydropyridine compounds and the microbial process for the stereoselection thereof MERCIAN CORPORATION (JP) 1997-06-03 US disclosed
EP-0657429-A1 OPTICALLY ACTIVE 1,4-DIHYDROPYRIDINE COMPOUND AND PROCESS FOR PRODUCING THE SAME MERCIAN CORPORATION (JP) 1995-06-14 EP disclosed
EP-0205339-B1 ANTIMICROBIAL AND ANTITUMOR PHENAZINE CARBOXALDEHYDES AND DERIVATIVES WARNER-LAMBERT COMPANY (US) 1990-02-07 EP disclosed
EP-0205339-B1 ANTIMICROBIAL AND ANTITUMOR PHENAZINE CARBOXALDEHYDES AND DERIVATIVES WARNER-LAMBERT COMPANY (US) 1990-02-07 EP disclosed
US-4738929-A 6-FORMYL-4,7,9-TRIHYDROXY-8-METHYL-1-PHENAZINECARBOXYLIC ACID, METHYL ESTER WARNER-LAMBERT COMPANY (US) 1988-04-19 US disclosed
US-4657909-A Antimicrobial and antitumor phenazine carboxaldehydes and derivatives WARNER-LAMBERT COMPANY (US) 1987-04-14 US disclosed
US-4657909-A Antimicrobial and antitumor phenazine carboxaldehydes and derivatives WARNER-LAMBERT COMPANY (US) 1987-04-14 US disclosed
EP-0205339-A1 Antimicrobial and antitumor phenazine carboxaldehydes and derivatives WARNER-LAMBERT COMPANY (US) 1986-12-17 EP disclosed
EP-0205339-A1 Antimicrobial and antitumor phenazine carboxaldehydes and derivatives WARNER-LAMBERT COMPANY (US) 1986-12-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10913936-B2 Phenazine degrading agents and related compositions, methods and systems for interfering with viability of bacteria PGLS, CLPP, BLVRB NQO2 556/4885ALDH1A1 1284/4885MAPT 3085/4885
US-20210032603-A1 PHENAZINE DEGRADING AGENTS AND RELATED COMPOSITIONS, METHODS AND SYSTEMS FOR INTERFERING WITH VIABILITY OF BACTERIA PGLS, CLPP, BLVRB NQO2 556/4885ALDH1A1 1284/4885MAPT 3085/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.