Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.37 |
| ▸ | TUBB | P07437 | 5/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.37 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.37 |
| ▸ | TUBB8 | Q3ZCM7 | 5/20 | 0.37 |
| ▸ | TUBA3E | Q6PEY2 | 5/20 | 0.37 |
| ▸ | TUBA1A | Q71U36 | 5/20 | 0.37 |
| ▸ | TUBA1C | Q9BQE3 | 5/20 | 0.37 |
| ▸ | TUBB6 | Q9BUF5 | 5/20 | 0.37 |
| ▸ | TUBB2B | Q9BVA1 | 5/20 | 0.37 |
| ▸ | TUBB1 | Q9H4B7 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004545 | 0.77 | NPSR1 (0.44) | NPSR1LMNATSHRALDH1A1GFER | |
| SCHEMBL6007018 | 0.77 | NPSR1 (0.44) | NPSR1LMNATSHRALDH1A1GFER | |
| SCHEMBL6005843 | 0.75 | LMNA (0.43) | NPSR1LMNATSHRCYP1A2ALDH1A1 | |
| SCHEMBL6006605 | 0.74 | LMNA (0.44) | NPSR1LMNATSHRCYP1A2ALDH1A1 | |
| SCHEMBL29950954 | 0.71 | KDM4E (0.38) | NPSR1LMNACYP1A2ALDH1A1GFER | |
| SCHEMBL6007089 | 0.70 | KDM4E (0.46) | NPSR1LMNACYP1A2ALDH1A1GFER | |
| SCHEMBL6006801 | 0.70 | LMNA (0.43) | NPSR1LMNATSHRCYP1A2ALDH1A1 | |
| SCHEMBL6007023 | 0.69 | CTSK (0.33) | CTSKCTSS | |
| SCHEMBL8056920 | 0.68 | MAPKAPK2 (0.35) | NPSR1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL6004882 | 0.68 | KDM4E (0.46) | NPSR1LMNACYP1A2ALDH1A1GFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7132437-B2 | for example, methyl 4'-[(3,5-dibutyl-1H-1,2,4-triazol-1-yl)methyl][1,1'-biphenyl]-2-carboxylate; for treatment of congestive heart failure | G.D. SEARLE (US) | 2006-11-07 | — | — | US | disclosed |
| US-20040220245-A1 | for example, methyl 4'-[(3,5-dibutyl-1H-1,2,4-triazol-1-yl)methyl][1,1'-biphenyl]-2-carboxylate; for treatment of congestive heart failure | G.D. SEARLE & CO., | 2004-11-04 | — | — | US | disclosed |
| US-20040121989-A1 | such as methyl 4'-[(3,5-dibutyl-1H-1,2,4-triazol-1-yl)methyl][1,1'-biphenyl]-2-carboxylate; for treatment of congestive heart failure | G.D. SEARLE & CO. | 2004-06-24 | — | — | US | disclosed |
| US-5217985-A | RENAL-SELECTIVE BIPHENYLALKYL 1H-SUBSTITUTED-1,2,4-TRIAZOLE ANGIOTENSIN II ANTAGONISTS FOR TREATMENT OF HYPERTENSION | G. D. SEARLE & CO. (US) | 1993-06-08 | — | — | US | disclosed |
| WO-1992004335-A2 | RENAL-SELECTIVE BIPHENYLALKYL 1H-SUBSTITUTED-1,2,4-TRIAZOLE ANGIOTENSIN II ANTAGONISTS FOR TREATMENT OF HYPERTENSION | G.D. SEARLE & CO. (US) | 1992-03-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040220245-A1 | for example, methyl 4'-[(3,5-dibutyl-1H-1,2,4-triazol-1-yl)methyl][1,1'-biphenyl]-2-carboxylate; for treatment of congestive heart failure | GLS, AGTR1, AGTR2 | ALPL 2845/4885SMN1; SMN2 4593/4885NPSR1 2742/4885 |
| US-20040121989-A1 | such as methyl 4'-[(3,5-dibutyl-1H-1,2,4-triazol-1-yl)methyl][1,1'-biphenyl]-2-carboxylate; for treatment of congestive heart failure | GLS, AGTR1, AGTR2 | ALPL 2730/4885SMN1; SMN2 4565/4885NPSR1 2823/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.