Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6009895 | 1.00 | ALOX5 (0.63) | ALOX5ALDH1A1MEN1POLBKMT2A | |
| SCHEMBL9743235 | 0.84 | ALOX5 (0.52) | ALOX5ALDH1A1MEN1POLBKMT2A | |
| SCHEMBL9743226 | 0.84 | ALOX5 (0.52) | ALOX5ALDH1A1MEN1POLBKMT2A | |
| SCHEMBL9742089 | 0.80 | KDM4E (0.55) | ALOX5ALDH1A1MEN1POLBKMT2A | |
| SCHEMBL9742084 | 0.80 | KDM4E (0.55) | ALOX5ALDH1A1MEN1POLBKMT2A | |
| SCHEMBL9877335 | 0.80 | TRPM8 (0.60) | ALOX5ALDH1A1POLBKMT2ARAB9A | |
| SCHEMBL9743407 | 0.78 | NPC1 (0.50) | ALOX5ALDH1A1LMNARAB9AMAPT | |
| SCHEMBL9743404 | 0.78 | NPC1 (0.50) | ALOX5ALDH1A1LMNARAB9AMAPT | |
| SCHEMBL29470147 | 0.78 | ALOX5 (1.00) | ALOX5ALDH1A1MEN1POLBKMT2A | |
| SCHEMBL9743831 | 0.76 | CA12 (0.60) | ALOX5ALDH1A1MEN1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5096919-A | Pyrrolylphenyl-substituted hydroxamic acid derivatives | CIBA-GEIGY CORPORATION (US) | 1992-03-17 | — | — | US | claimed |
| EP-0378991-A1 | Certain pyrrolylphenyl-substituted hydroxamic acid derivatives | CIBA-GEIGY AG (CH) | 1990-07-25 | — | — | EP | claimed |
| US-7132441-B2 | Immunosuppressive effects of administration of a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor | G.D. SEARLE & CO. (US) | 2006-11-07 | — | — | US | disclosed |
| WO-1994012667-A1 | INHIBITORS OF ARACHIDONIC ACID METABOLITES FOR PREVENTING NEUROLOGICAL DAMAGE | THE UNITED STATES DEPARTMENT OF THE ARMY (US) | 1994-06-09 | — | — | WO | disclosed |
| US-5096919-A | Pyrrolylphenyl-substituted hydroxamic acid derivatives | CIBA-GEIGY CORPORATION (US) | 1992-03-17 | — | — | US | disclosed |
| EP-0378991-A1 | Certain pyrrolylphenyl-substituted hydroxamic acid derivatives | CIBA-GEIGY AG (CH) | 1990-07-25 | — | — | EP | disclosed |