Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9743404 | 1.00 | NPC1 (0.50) | NPC1ALDH1A1LMNAMAPTRAB9A | |
| SCHEMBL8564143 | 0.78 | HCAR2 (0.59) | NPC1ALDH1A1LMNAMAPTRAB9A | |
| SCHEMBL8564140 | 0.78 | HCAR2 (0.59) | NPC1ALDH1A1LMNAMAPTRAB9A | |
| SCHEMBL6009904 | 0.78 | ALOX5 (0.63) | ALDH1A1LMNAMAPTRAB9AALOX5 | |
| SCHEMBL6009895 | 0.78 | ALOX5 (0.63) | ALDH1A1LMNAMAPTRAB9AALOX5 | |
| SCHEMBL10457551 | 0.78 | ALOX5 (0.67) | NPC1ALDH1A1LMNAMAPTRAB9A | |
| SCHEMBL8993860 | 0.78 | ALOX5 (0.67) | NPC1ALDH1A1LMNAMAPTRAB9A | |
| SCHEMBL9877335 | 0.76 | TRPM8 (0.60) | ALDH1A1MAPTRAB9AALOX5PTGS1 | |
| SCHEMBL9877155 | 0.76 | HDAC2 (0.57) | NPC1ALOX5PTGS1PTGS2L3MBTL1 | |
| SCHEMBL10569133 | 0.75 | HSD11B1 (0.60) | LMNAMAPTALOX5PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5096919-A | Pyrrolylphenyl-substituted hydroxamic acid derivatives | CIBA-GEIGY CORPORATION (US) | 1992-03-17 | — | — | US | disclosed |
| EP-0378991-A1 | Certain pyrrolylphenyl-substituted hydroxamic acid derivatives | CIBA-GEIGY AG (CH) | 1990-07-25 | — | — | EP | disclosed |