Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 7/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PI4KA | P42356 | 3/20 | 0.34 |
| ▸ | PI4K2B | Q8TCG2 | 3/20 | 0.34 |
| ▸ | PI4K2A | Q9BTU6 | 3/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.32 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24284150 | 0.85 | ALDH1A1 (0.35) | ADORA2AALDH1A1PI4KAPI4K2BPI4K2A | |
| SCHEMBL11146247 | 0.75 | KDM4E (0.42) | ADORA2AALDH1A1PI4KAPI4K2BPI4K2A | |
| SCHEMBL31694562 | 0.72 | ADORA2A (0.39) | ADORA2AADORA1ADORA2B | |
| SCHEMBL24284140 | 0.69 | MBOAT4 (0.36) | ADORA2AALDH1A1PI4KAPI4K2BPI4K2A | |
| SCHEMBL31694571 | 0.69 | EGLN2 (0.46) | ADORA2AALDH1A1ADORA1ADORA2BTSHR | |
| SCHEMBL24284144 | 0.68 | TSHR (0.38) | ALDH1A1XDHENPP1TSHREGLN2 | |
| SCHEMBL5653328 | 0.67 | ADORA2A (0.46) | ADORA2AALDH1A1ADORA1ADORA2BADORA3 | |
| SCHEMBL21731197 | 0.67 | ADORA2A (0.36) | ADORA2AALDH1A1XDHMBOAT4HTT | |
| SCHEMBL15263323 | 0.66 | PDE10A (0.52) | ADORA2AALDH1A1ADORA1ADORA2BADORA3 | |
| SCHEMBL29646392 | 0.66 | PDE10A (0.52) | ADORA2AALDH1A1ADORA1ADORA2BADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1618109-A2 | TRIAZOLO[1,5-C]PYRIMIDINES AND PYRAZOLO[1,5-C]PYRIMIDINES USEFUL AS A2A ADENOSINE RECEPTOR ANTAGONISTS | Biogen Idec MA Inc. (US) | 2006-01-25 | — | — | EP | claimed |
| WO-2004092172-A2 | TRIAZOLO[1,5-C]PYRIMIDINES AND PYRAZOLO[1,5-C]PYRIMIDINES USEFUL AS A2A ADENOSIN E RECEPTOR ANTAGONISTS | BIOGEN IDEC MA INC. (US) | 2004-10-28 | — | — | WO | claimed |