Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 13/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 13/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 10/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 10/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5103140 | 0.78 | KDM4E (0.51) | ADORA2AADORA1ADORA2BADORA3KDM4E | |
| SCHEMBL5653498 | 0.71 | IRAK4 (0.37) | ADORA2AADORA1ADORA2BADORA3MAPK1 | |
| SCHEMBL21731209 | 0.70 | ADORA2A (0.51) | ADORA2AADORA1ADORA2BKDM4EALDH1A1 | |
| SCHEMBL6010018 | 0.67 | ADORA2A (0.38) | ADORA2AADORA1ADORA2BADORA3ALDH1A1 | |
| SCHEMBL23828527 | 0.67 | ALDH1A1 (0.47) | ADORA2AADORA1ADORA2BADORA3KDM4E | |
| SCHEMBL29646392 | 0.64 | PDE10A (0.52) | ADORA2AADORA1ADORA2BADORA3KDM4E | |
| SCHEMBL15263323 | 0.64 | PDE10A (0.52) | ADORA2AADORA1ADORA2BADORA3KDM4E | |
| SCHEMBL19837985 | 0.63 | ALDH1A1 (0.45) | ADORA2AADORA1ADORA2BADORA3KDM4E | |
| SCHEMBL7334935 | 0.62 | KDM4E (0.40) | ADORA2AADORA1ADORA2BADORA3KDM4E | |
| SCHEMBL3548828 | 0.62 | ADORA2A (0.68) | ADORA2AADORA1ADORA2BADORA3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070010522-A1 | Triazolo[1,5-c]pyrimidines and pyrazolo[1,5-c]pyrimidines useful as a2a adenosine receptor antagonists | BIOGEN IDEC MA INC. | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010522-A1 | Triazolo[1,5-c]pyrimidines and pyrazolo[1,5-c]pyrimidines useful as a2a adenosine receptor antagonists | ADORA2A, ADORA3, ADORA1 | ADORA2A 1/4885ADORA1 3/4885ADORA2B 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.