SCHEMBL6010786

SCHEMBL6010786

OCc1cc(Cl)cc2nc(S)oc12

nearest known ligand 0.40

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ESR2 Q92731 1/20 0.40
S1PR3 Q99500 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6010882 0.83 ESR1 (0.39) ESR2
SCHEMBL16391333 0.81 ESR1 (0.42) ESR2
SCHEMBL6010774 0.77 AHR (0.36)
SCHEMBL16391300 0.74 MAOB (0.36) ESR2
SCHEMBL6275934 0.74 MTNR1A (0.38) ESR2
SCHEMBL5021458 0.74 NUDT1 (0.41)
SCHEMBL9101380 0.71 FBP1 (0.33)
SCHEMBL16391312 0.71 MAOB (0.41) ESR2
SCHEMBL16391290 0.70 GPR35 (0.40) ESR2
SCHEMBL16391287 0.70 GABRA1 (0.40) ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7045516-B1 Benzoxazole derivatives and drugs containing the same as the active ingredient KOICHI SHUDO (JP) 2006-05-16 US disclosed
EP-1134220-B1 BENZOXAZOLE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT SHUDO KOICHI (JP) 2004-08-18 EP disclosed
CN-1333771-A Benzoxazole derivative and drug containing the same as active ingredient MEIJI SEIKA KAISHA (JP) 2002-01-30 CN disclosed
EP-1134220-A1 BENZOXAZOLE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT MEIJI SEIKA KAISHA LTD. (JP) 2001-09-19 EP disclosed