Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.58 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.52 |
| ▸ | NMT1 | P30419 | 2/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4311359 | 0.86 | NMT1 (0.48) | HTR6NMT1CHRNB2CHRNA4EPHX2 | |
| SCHEMBL2385259 | 0.85 | HRH4 (0.48) | HRH4EPHX2CYP3A4HTR1ASLC6A2 | |
| SCHEMBL4320113 | 0.81 | CHRNB2 (0.48) | CHRNB2CHRNA4EPHX2 | |
| Hydrochloric Acid SCHEMBL7059560 | 0.79 | HTR2C (0.58) | HTR6HRH4HTR1ACHRM1CHRM3 | |
| SCHEMBL4674253 | 0.78 | HTR6 (0.59) | HTR6NMT1PDE3BPDE3ACHRNB2 | |
| SCHEMBL4313551 | 0.77 | CHKA (0.47) | EPHX2SLC6A4 | |
| SCHEMBL4320992 | 0.77 | HRH4 (0.50) | HTR6HRH4HTR1A | |
| SCHEMBL4313634 | 0.76 | HTR1A (0.47) | HTR6EPHX2HTR1ASLC6A2SLC6A4 | |
| SCHEMBL4314576 | 0.75 | HTR6 (0.48) | HTR6HRH4EPHX2HTR1ASLC6A2 | |
| SCHEMBL29664303 | 0.75 | HTR6 (0.58) | HTR6HRH4NMT1PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1620081-A2 | TREATMENT OF INCONTINENCE WITH 5HTC2 AGONISTS | Pfizer Limited (GB) | 2006-02-01 | — | — | EP | disclosed |
| WO-2004096196-A2 | TREATMENT OF INCONTINENCE WITH 5HTC2 AGONISTS | PFIZER LIMITED (GB) | 2004-11-11 | — | — | WO | disclosed |