Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPR | P35270 | 14/20 | 0.33 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1573851 | 0.90 | SPR (0.37) | SPR | |
| SCHEMBL1573937 | 0.87 | LIPE (0.38) | SPR | |
| SCHEMBL1573846 | 0.86 | HRH3 (0.36) | SPRHRH3 | |
| SCHEMBL1573785 | 0.81 | SPR (0.37) | SPR | |
| SCHEMBL1573472 | 0.80 | SPR (0.36) | SPR | |
| SCHEMBL1573883 | 0.79 | GAA (0.41) | HRH3 | |
| SCHEMBL1573836 | 0.74 | GAA (0.36) | HRH3 | |
| SCHEMBL1573885 | 0.71 | GAA (0.36) | — | |
| SCHEMBL1573736 | 0.70 | SPR (0.35) | SPR | |
| SCHEMBL1573859 | 0.69 | GAA (0.41) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713779-A1 | INDAZOLE DERIVATIVES AS INHIBITORS OF HORMONE-SENSITIVE LIPASES | Sanofi-Aventis Deutschland GmbH (DE) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005073199-A1 | INDAZOLE DERIVATIVES AS INHIBITORS OF HORMONE-SENSITIVE LIPASES | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2005-08-11 | — | — | WO | disclosed |