Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6015956 | 0.89 | POLB (0.52) | KMT2AKDM4EPOLBGAASMN1; SMN2 | |
| SCHEMBL6016081 | 0.84 | TSHR (0.52) | KMT2ANPSR1ALDH1A1CYP2D6KDM4E | |
| SCHEMBL6015745 | 0.77 | KDM4E (0.46) | NPSR1ALDH1A1CYP2D6KDM4EPOLB | |
| SCHEMBL15495602 | 0.74 | KMT2A (0.45) | KMT2ANPSR1ALDH1A1CYP2D6KDM4E | |
| SCHEMBL4283848 | 0.70 | ALDH1A1 (0.81) | KMT2ANPSR1ALDH1A1KDM4EPOLB | |
| SCHEMBL6016084 | 0.70 | HDAC4 (0.34) | — | |
| SCHEMBL15495676 | 0.69 | CYP2D6 (0.47) | KMT2AALDH1A1CYP2D6KDM4EPOLB | |
| SCHEMBL7615075 | 0.69 | TBXAS1 (0.40) | — | |
| SCHEMBL2067370 | 0.69 | POLB (0.46) | KMT2AALDH1A1POLBMAPK1SMN1; SMN2 | |
| SCHEMBL6015620 | 0.68 | HTT (0.50) | KMT2ACYP2D6KDM4EPOLBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1181282-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-27 | — | — | EP | claimed |
| WO-2000075139-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2000-12-14 | — | — | WO | claimed |
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | disclosed |