Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 6/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | PYGL | P06737 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9581656 | 0.83 | L3MBTL1 (0.40) | HPGDALDH1A1KMT2AL3MBTL1LMNA | |
| SCHEMBL6016001 | 0.81 | KDM4E (0.46) | HPGDPOLBALDH1A1KMT2AMEN1 | |
| SCHEMBL6015935 | 0.78 | PIM1 (0.46) | HPGDPOLBALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL9581327 | 0.78 | PLK1 (0.45) | POLBGAAKMT2AL3MBTL1KDM4E | |
| SCHEMBL6015658 | 0.76 | CYP1A2 (0.47) | HPGDPOLBALDH1A1KMT2AMEN1 | |
| SCHEMBL6015695 | 0.76 | DRD2 (0.47) | MAPK1POLBALDH1A1GAAKMT2A | |
| SCHEMBL6015934 | 0.75 | POLR1A (0.40) | MAPK1POLBALDH1A1GAAKMT2A | |
| SCHEMBL6015783 | 0.75 | ALDH1A1 (0.49) | HPGDPOLBALDH1A1KMT2AMEN1 | |
| SCHEMBL6015635 | 0.74 | BCL3 (0.56) | HPGDALDH1A1GAAKMT2AMEN1 | |
| SCHEMBL7616717 | 0.73 | PBK (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | claimed |
| EP-1181282-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-27 | — | — | EP | claimed |
| WO-2000075139-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2000-12-14 | — | — | WO | claimed |
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | disclosed |