Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | POLR1A | O95602 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6015719 | 0.99 | POLR1A (0.46) | CYP1A2CYP2D6CYP2C9KDM4EHSD17B10 | |
| SCHEMBL6015635 | 0.88 | BCL3 (0.56) | MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL6015695 | 0.83 | DRD2 (0.47) | KDM4EHSD17B10KMT2AALDH1A1POLB | |
| SCHEMBL6015846 | 0.76 | MAPK1 (0.50) | KDM4EHSD17B10MEN1KMT2AALDH1A1 | |
| SCHEMBL7531492 | 0.76 | CYP1A2 (0.62) | CYP1A2CYP2D6CYP2C9KDM4EHSD17B10 | |
| SCHEMBL6015678 | 0.75 | HTR3A (0.56) | CYP1A2CYP2D6CYP2C9KDM4EHSD17B10 | |
| SCHEMBL9581656 | 0.75 | L3MBTL1 (0.40) | KMT2AALDH1A1HPGDLMNA | |
| SCHEMBL2964718 | 0.74 | IKBKB (0.57) | CYP1A2CYP2D6CYP2C9KDM4EHSD17B10 | |
| SCHEMBL15495306 | 0.74 | ALOX5 (0.60) | CYP1A2CYP2D6CYP2C9KDM4EPOLR1A | |
| SCHEMBL6015966 | 0.74 | HTR3A (0.54) | CYP1A2CYP2D6CYP2C9KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | claimed |
| EP-1181282-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-27 | — | — | EP | claimed |
| WO-2000075139-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2000-12-14 | — | — | WO | claimed |
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | disclosed |