Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27620291 | 0.82 | KDM4E (0.34) | KDM4ECYP1A2TSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL4168685 | 0.81 | GRIN1 (0.44) | TSHRSMN1; SMN2 | |
| SCHEMBL6015764 | 0.76 | PRKCA (0.42) | KDM4ECYP1A2TSHRSMN1; SMN2MAPT | |
| SCHEMBL17956205 | 0.72 | HTR2C (0.51) | CYP1A2ALDH1A1 | |
| SCHEMBL10397184 | 0.68 | PTGS2 (0.57) | HTTALOX15KDM4ESMN1; SMN2MAPT | |
| SCHEMBL6015850 | 0.67 | DNM1 (0.44) | HTTP2RX4ALOX15KDM4ETSHR | |
| SCHEMBL6015870 | 0.67 | ALDH1A1 (0.54) | HTTKDM4ECYP1A2TSHRSMN1; SMN2 | |
| SCHEMBL1557707 | 0.66 | DNM1 (0.43) | P2RX4ALOX15KDM4ETSHRMAPT | |
| SCHEMBL7617275 | 0.66 | KDM4E (0.46) | P2RX4ALOX15KDM4EALDH1A1CYP2C9 | |
| SCHEMBL7093719 | 0.65 | CNR1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | claimed |
| EP-1181282-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-27 | — | — | EP | claimed |
| WO-2000075139-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2000-12-14 | — | — | WO | claimed |
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | disclosed |