Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 13/20 | 0.39 |
| ▸ | PPARD | Q03181 | 13/20 | 0.39 |
| ▸ | PPARG | P37231 | 5/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5617383 | 0.93 | PPARD (0.43) | PPARAPPARDPPARGFFAR1 | |
| SCHEMBL6017230 | 0.90 | PKM (0.38) | PPARAPPARDPPARGTRPV1 | |
| SCHEMBL6017240 | 0.86 | KDM4E (0.43) | PPARAPPARDPPARGTRPV1 | |
| SCHEMBL6017580 | 0.83 | MAOB (0.40) | PPARAPPARDTRPV1 | |
| SCHEMBL1227421 | 0.80 | PTGDR2 (0.41) | FFAR1 | |
| SCHEMBL5617384 | 0.79 | PPARD (0.45) | PPARAPPARDPPARGTRPV1 | |
| SCHEMBL6052643 | 0.79 | PPARA (0.48) | PPARAPPARDPPARG | |
| SCHEMBL1378661 | 0.78 | PPARD (0.59) | PPARAPPARDPPARG | |
| SCHEMBL5628880 | 0.77 | PPARD (0.49) | PPARAPPARDPPARG | |
| SCHEMBL6017387 | 0.77 | TRPV1 (0.40) | PPARAPPARDPPARGTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682535-A1 | HETEROARYL DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005049606-A1 | HETEROARYL DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-02 | — | — | WO | disclosed |