Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | ICMT | O60725 | 2/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 3/20 | 0.36 |
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
| ▸ | GSTP1 | P09211 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6017580 | 0.94 | MAOB (0.40) | TRPV1MAOBPKMPPARDPPARA | |
| SCHEMBL6017240 | 0.90 | KDM4E (0.43) | TRPV1ICMTPPARDPPARAPPARG | |
| SCHEMBL6017371 | 0.89 | TRPV1 (0.45) | TRPV1MAOBPKMTRPM8ICMT | |
| SCHEMBL6017230 | 0.87 | PKM (0.38) | TRPV1MAOBPKMPPARDPPARA | |
| SCHEMBL6017575 | 0.85 | TRPV1 (0.46) | TRPV1MAOBPKMTRPM8ICMT | |
| SCHEMBL5617383 | 0.84 | PPARD (0.43) | MAOBPPARDPPARAPPARG | |
| SCHEMBL1550166 | 0.81 | PPARD (0.49) | MAOBPPARDPPARAGSTP1PPARG | |
| SCHEMBL5617133 | 0.80 | KDM4E (0.48) | TRPV1ICMTPPARDPPARAPPARG | |
| SCHEMBL6030172 | 0.79 | PPARD (0.44) | MAOBPPARDPPARAGSTP1 | |
| SCHEMBL6029336 | 0.78 | PPARD (0.51) | MAOBPPARDPPARAGSTP1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682535-A1 | HETEROARYL DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005049606-A1 | HETEROARYL DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-02 | — | — | WO | disclosed |