Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 7/20 | 0.37 |
| ▸ | PPARA | Q07869 | 6/20 | 0.37 |
| ▸ | GSTP1 | P09211 | 3/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | FOS | P01100 | 1/20 | 0.34 |
| ▸ | JUN | P05412 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6017387 | 0.94 | TRPV1 (0.40) | MAOBPKMPPARDPPARAGSTP1 | |
| SCHEMBL6017230 | 0.93 | PKM (0.38) | MAOBPKMPPARDPPARAGSTP1 | |
| SCHEMBL5617383 | 0.90 | PPARD (0.43) | MAOBPPARDPPARA | |
| SCHEMBL6017240 | 0.84 | KDM4E (0.43) | PPARDPPARANFKB1TRPV1 | |
| SCHEMBL6017141 | 0.83 | PPARA (0.39) | PPARDPPARATRPV1 | |
| SCHEMBL6017371 | 0.83 | TRPV1 (0.45) | MAOBPKMPPARDPPARAGSTP1 | |
| SCHEMBL6017361 | 0.81 | PKM (0.42) | MAOBPKMPPARDPPARAIGF1R | |
| SCHEMBL1550166 | 0.81 | PPARD (0.49) | MAOBPPARDPPARAGSTP1 | |
| SCHEMBL6017372 | 0.80 | PKM (0.43) | MAOBPKMPPARDPPARAIGF1R | |
| SCHEMBL6017575 | 0.79 | TRPV1 (0.46) | MAOBPKMPPARDPPARAGSTP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682535-A1 | HETEROARYL DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005049606-A1 | HETEROARYL DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-02 | — | — | WO | disclosed |