Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.34 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.33 |
| ▸ | RARA | P10276 | 2/20 | 0.32 |
| ▸ | RARB | P10826 | 2/20 | 0.32 |
| ▸ | RARG | P13631 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.32 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3998188 | 0.81 | CYP26A1 (0.49) | CYP26A1CYP26B1AKR1B1RARARARB | |
| SCHEMBL6146444 | 0.81 | CYP26A1 (0.50) | CYP26A1CYP26B1AKR1B1RARARARB | |
| SCHEMBL9053853 | 0.80 | ALDH1A1 (0.42) | AKR1B1RARARARBRARGMAPT | |
| SCHEMBL9054289 | 0.75 | MAPT (0.41) | AKR1B1MAPT | |
| SCHEMBL4373634 | 0.75 | LMNA (0.42) | MAPT | |
| Hydrochloric Acid SCHEMBL21750681 | 0.74 | MAPT (0.44) | AKR1B1MAPT | |
| SCHEMBL8101913 | 0.73 | RARB (0.53) | CYP26A1CYP26B1AKR1B1RARARARB | |
| SCHEMBL4421853 | 0.73 | KDM4E (0.50) | CYP26A1CYP26B1AKR1B1RARARARB | |
| SCHEMBL4945442 | 0.73 | RARA (0.38) | CYP26A1CYP26B1AKR1B1RARARARB | |
| SCHEMBL6147589 | 0.72 | TAS1R3 (0.34) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1704139-A1 | DISUBSTITUTED CHALCONE OXIMES AS SELECTIVE AGONISTS OF RAR y RETINOID RECEPTORS | Allergan, Inc. (US) | 2006-09-27 | — | — | EP | disclosed |
| WO-2005066116-A1 | DISUBSTITUTED CHALCONE OXIMES AS SELECTIVE AGONISTS OF RARϜ RETINOID RECEPTORS | ALLERGAN, INC. (US) | 2005-07-21 | — | — | WO | disclosed |