Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 6/20 | 0.38 |
| ▸ | RARB | P10826 | 6/20 | 0.38 |
| ▸ | RARG | P13631 | 6/20 | 0.38 |
| ▸ | RXRA | P19793 | 2/20 | 0.38 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.34 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8101913 | 0.79 | RARB (0.53) | RARARARBRARGRXRACYP26A1 | |
| SCHEMBL4421853 | 0.79 | KDM4E (0.50) | RARARARBRARGRXRACYP26A1 | |
| SCHEMBL8907172 | 0.75 | ATM (0.43) | RARARARBRARGRXRACYP26A1 | |
| SCHEMBL27557340 | 0.75 | RARB (0.45) | RARARARBRARGRXRACYP26A1 | |
| SCHEMBL9053853 | 0.75 | ALDH1A1 (0.42) | RARARARBRARGAKR1B1 | |
| SCHEMBL8109801 | 0.74 | CYP26A1 (0.46) | RARARARBRARGRXRACYP26A1 | |
| SCHEMBL9054289 | 0.73 | MAPT (0.41) | AKR1B1KDM4E | |
| SCHEMBL6017429 | 0.73 | CHRM2 (0.35) | RARARARBRARGCYP26A1CYP26B1 | |
| SCHEMBL7141574 | 0.72 | RARB (0.74) | RARARARBRARGRXRACYP26A1 | |
| Hydrochloric Acid SCHEMBL21750681 | 0.72 | MAPT (0.44) | AKR1B1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7414143-B2 | Process for the preparation of 4,4-dimethyl-6-ethynylthiochroman | GLENMARK PHARMACEUTICALS LIMITED (IN) | 2008-08-19 | — | — | US | disclosed |
| US-20070238881-A1 | Process for the preparation of tazarotene intermediates and use thereof for the preparation of tazarotene | GLENMARK PHARMACEUTICALS LIMITED (IN) | 2007-10-11 | — | — | US | disclosed |
| US-20060106233-A1 | Process for the preparation of disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups | GLENMARK PHARMACEUTICALS LIMITED (IN) | 2006-05-18 | — | — | US | disclosed |
| WO-2005123713-A1 | PROCESS FOR THE PREPARATION OF DISUBSTITUTED ACETYLENES BEARING HETEROAROMATIC AND HETEROBICYCLIC GROUPS | GLENMARK PHARMACEUTICALS LIMITED (US) | 2005-12-29 | — | — | WO | disclosed |
| US-6963002-B2 | Process for the preparation of 4,4-dimethyl-6-ethynylthiochroman | GLENMARK PHARMACEUTICALS LIMITED (US) | 2005-11-08 | — | — | US | disclosed |
| US-20050240029-A1 | Process for the preparation of 4,4-dimethyl-6-ethynylthiochroman | GLENMARK PHARMACEUTICALS LIMITED (IN) | 2005-10-27 | — | — | US | disclosed |
| US-20050004373-A1 | Process for the preparation of 4,4-dimethyl-6-ethynylthiochroman | GLENMARK GENERICS LTD. (IN) | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070238881-A1 | Process for the preparation of tazarotene intermediates and use thereof for the preparation of tazarotene | NAMPT, NAPRT, NNT | RARA 1989/4885RARB 2078/4885RARG 2738/4885 |
| US-20050240029-A1 | Process for the preparation of 4,4-dimethyl-6-ethynylthiochroman | YAP1, SDHA, SDHB | RARA 1195/4885RARB 1175/4885RARG 1361/4885 |
| US-20050004373-A1 | Process for the preparation of 4,4-dimethyl-6-ethynylthiochroman | YAP1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, SDHA | RARA 1124/4885RARB 1135/4885RARG 1336/4885 |
| US-20060106233-A1 | Process for the preparation of disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups | CBR3, NR1H2, NR3C2 | RARA 2569/4885RARB 2140/4885RARG 2656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.