Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.38 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6017362 | 0.85 | MAP4K4 (0.40) | HTTIRAK4 | |
| SCHEMBL2799673 | 0.74 | ALDH1A1 (0.59) | ALDH1A1MAPTLMNAEIF2AK2PDGFRB | |
| SCHEMBL2913027 | 0.70 | HTT (0.62) | ALDH1A1MAPTHTTLMNAPDGFRB | |
| SCHEMBL7474800 | 0.69 | ALDH1A1 (0.60) | ALDH1A1MAPTLMNAPDGFRB | |
| SCHEMBL7481750 | 0.67 | MAPT (0.57) | ALDH1A1MAPTLMNAPDGFRB | |
| SCHEMBL30254155 | 0.66 | ALDH1A1 (0.45) | ALDH1A1L3MBTL1CYP1A2SLC6A4 | |
| SCHEMBL29155320 | 0.66 | SIGMAR1 (0.45) | L3MBTL1 | |
| SCHEMBL28241913 | 0.66 | MAPK1 (0.50) | ALDH1A1MAPTLMNA | |
| SCHEMBL7480479 | 0.65 | NCF1 (0.62) | ALDH1A1HTR3EHTR3BCYP1A2CYP3A4 | |
| SCHEMBL7383181 | 0.65 | CYP3A4 (0.40) | ALDH1A1MAPTHTTL3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1684694-A2 | AKT PROTEIN KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005051304-A2 | AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2005-06-09 | — | — | WO | disclosed |