Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | GRM6 | O15303 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6018296 | 0.83 | MAPK1 (0.37) | PTGS2L3MBTL1 | |
| SCHEMBL1827223 | 0.81 | PTGS2 (0.39) | PTGS2GRM6TP53MDM2L3MBTL1 | |
| SCHEMBL6018662 | 0.74 | PTGS2 (0.40) | PTGS2GRM6TP53MDM2L3MBTL1 | |
| SCHEMBL1224397 | 0.68 | MAPT (0.56) | PTGS2GRM6L3MBTL1 | |
| SCHEMBL1824700 | 0.67 | MAPK1 (0.38) | GRM6L3MBTL1 | |
| SCHEMBL1826346 | 0.66 | GRM6 (0.41) | PTGS2GRM6TP53 | |
| SCHEMBL6018836 | 0.64 | PTGS2 (0.39) | PTGS2GRM6TP53MDM2L3MBTL1 | |
| SCHEMBL12811196 | 0.64 | MAPK1 (0.33) | — | |
| SCHEMBL28304213 | 0.64 | MAPT (0.42) | PTGS2GRM6L3MBTL1 | |
| SCHEMBL5718140 | 0.62 | MAPK1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1412347-B1 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC PENTALENE DERIVATIVES | BASELL POLYOLEFINE GMBH (DE) | 2006-01-11 | — | — | EP | disclosed |
| US-6930190-B2 | Process for the preparation of heterocyclic pentalene derivatives | BASELL POLYOLEFINE GMBH (DE) | 2005-08-16 | — | — | US | disclosed |
| US-20040192931-A1 | Process for the preparation of heterocyclic pentalene derivatives | EQUISTAR CHEMICALS, LP | 2004-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040192931-A1 | Process for the preparation of heterocyclic pentalene derivatives | CBR3, CBR1, ADH5 | PTGS2 268/4885GRM6 2066/4885TP53 3892/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.