Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6018584 | 0.89 | CYP3A4 (0.37) | CYP3A4L3MBTL1TSHRTDP1ATM | |
| SCHEMBL10621265 | 0.84 | CYP3A4 (0.47) | CYP3A4L3MBTL1TSHRTDP1ATM | |
| SCHEMBL9675719 | 0.80 | CYP3A4 (0.34) | CYP3A4L3MBTL1TSHRTDP1ATM | |
| SCHEMBL5892149 | 0.77 | CYP3A4 (0.55) | CYP3A4L3MBTL1TSHRTDP1ATM | |
| SCHEMBL4396918 | 0.76 | CYP3A4 (0.47) | CYP3A4L3MBTL1TSHRTDP1ATM | |
| SCHEMBL4268477 | 0.76 | ALDH1A1 (0.56) | CYP3A4L3MBTL1TSHRTDP1ATM | |
| SCHEMBL19123836 | 0.75 | CYP3A4 (0.52) | CYP3A4L3MBTL1TSHRTDP1ATM | |
| SCHEMBL8217857 | 0.74 | CYP3A4 (0.55) | CYP3A4L3MBTL1TSHRTDP1ATM | |
| SCHEMBL18427318 | 0.74 | CYP3A4 (0.62) | CYP3A4L3MBTL1TSHRTDP1ATM | |
| SCHEMBL4654193 | 0.74 | ALDH1A1 (0.54) | CYP3A4L3MBTL1TSHRTDP1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7135491-B2 | 5-Aryltetrazole compounds and uses thereof | INOTEK PHARMACEUTICALS CORP. (US) | 2006-11-14 | — | — | US | disclosed |
| US-7087631-B2 | Aryltetrazole compounds, and compositions thereof | INOTEK PHARMACEUTICALS CORPORATION (US) | 2006-08-08 | — | — | US | disclosed |
| US-20060135519-A2 | 5-ARYLTETRAZOLE COMPOUNDS AND COMPOSITIONS THEREOF | NIVOROZHKIN ALEXANDER | 2006-06-22 | — | — | US | disclosed |
| US-20050159418-A1 | 5-Aryltetrazoles compounds and compositions thereof | NIVOROZHKIN ALEX (US) | 2005-07-21 | — | — | US | disclosed |
| US-20050159467-A1 | 5-Aryltetrazole compounds and uses thereof | NIVOROZHKIN ALEX (US) | 2005-07-21 | — | — | US | disclosed |
| EP-1542980-A1 | 5-ARYLTETRAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND USES THEREFOR | Inotek Pharmaceuticals Corporation (US) | 2005-06-22 | — | — | EP | disclosed |
| US-20040116423-A1 | 5-Aryltetrazole compounds, compositions thereof, and uses therefor | INOTEK PHARMACEUTICALS CORPORATION | 2004-06-17 | — | — | US | disclosed |
| WO-2004009563-A1 | 5-ARYLTETRAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND USES THEREFOR | INOTEK PHARMACEUTICALS CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135519-A2 | 5-ARYLTETRAZOLE COMPOUNDS AND COMPOSITIONS THEREOF | CASP5, NOX5, IL5 | CYP3A4 336/4885L3MBTL1 1235/4885TSHR 2774/4885 |
| US-20050159467-A1 | 5-Aryltetrazole compounds and uses thereof | NLRP3, XDH, CASP5 | CYP3A4 325/4885L3MBTL1 723/4885TSHR 2226/4885 |
| US-20050159418-A1 | 5-Aryltetrazoles compounds and compositions thereof | NLRP3, CASP5, CASP3 | CYP3A4 338/4885L3MBTL1 889/4885TSHR 2648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.