Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SCD | O00767 | 2/20 | 0.36 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12905357 | 0.83 | MAPT (0.38) | RAB9AMEN1KMT2AMAPTLMNA | |
| Hydrochloric Acid SCHEMBL601780 | 0.82 | MMP2 (0.39) | RAB9AMEN1KMT2ALMNANPC1 | |
| SCHEMBL1108033 | 0.82 | RAB9A (0.55) | RAB9AMEN1KMT2AMAPTLMNA | |
| SCHEMBL3788645 | 0.82 | MEN1 (0.41) | RAB9AMEN1KMT2AMAPTLMNA | |
| Hydrochloric Acid SCHEMBL600761 | 0.80 | ALDH1A1 (0.39) | RAB9AMEN1KMT2AMAPTLMNA | |
| Hydrochloric Acid SCHEMBL602853 | 0.79 | RAB9A (0.36) | RAB9AMEN1KMT2AMAPTLMNA | |
| SCHEMBL12544643 | 0.79 | RAB9A (0.56) | RAB9AMEN1KMT2AMAPTLMNA | |
| SCHEMBL12239728 | 0.79 | RAB9A (0.50) | RAB9AMEN1KMT2AMAPTLMNA | |
| Hydrochloric Acid SCHEMBL194414 | 0.79 | PGK1 (0.37) | — | |
| Hydrochloric Acid SCHEMBL6446792 | 0.79 | RAB9A (0.38) | RAB9AMEN1KMT2AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8786932-B2 | Advanced electrode structures and electrochromic devices | NTERA, INC. (US) | 2014-07-22 | — | — | US | claimed |
| US-20120038967-A1 | ADVANCED ELECTRODE STRUCTURES AND ELECTROCHROMIC DEVICES | NTERA LIMITED (IE) | 2012-02-16 | — | — | US | claimed |
| US-8786932-B2 | Advanced electrode structures and electrochromic devices | NTERA, INC. (US) | 2014-07-22 | — | — | US | disclosed |
| US-20120038967-A1 | ADVANCED ELECTRODE STRUCTURES AND ELECTROCHROMIC DEVICES | NTERA LIMITED (IE) | 2012-02-16 | — | — | US | disclosed |