Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2428407 | 0.88 | MAPK9 (0.53) | POLBSMN1; SMN2NPC1ALDH1A1LMNA | |
| SCHEMBL7435212 | 0.81 | MAPK9 (0.48) | POLBSMN1; SMN2NPC1ALDH1A1LMNA | |
| SCHEMBL2423853 | 0.80 | MAPK9 (0.54) | POLBSMN1; SMN2ALDH1A1LMNAMEN1 | |
| SCHEMBL4965751 | 0.76 | SMN1; SMN2 (0.53) | POLBSMN1; SMN2ALDH1A1LMNAMEN1 | |
| SCHEMBL3479993 | 0.72 | MAPK9 (0.51) | POLBSMN1; SMN2NPC1ALDH1A1LMNA | |
| SCHEMBL5564833 | 0.71 | ALDH1A1 (0.44) | POLBSMN1; SMN2ALDH1A1LMNAMEN1 | |
| SCHEMBL7894669 | 0.70 | MAPK9 (0.59) | POLBALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL6431701 | 0.70 | MAPK9 (0.59) | POLBALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL2423054 | 0.70 | MAPK9 (0.59) | POLBSMN1; SMN2ALDH1A1LMNAMEN1 | |
| SCHEMBL3480648 | 0.69 | MAPK9 (0.60) | SMN1; SMN2ALDH1A1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663193-A1 | SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF DIABETES | Applied Research Systems ARS Holding N.V. (AN) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005025558-A1 | SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF DIABETES | APPLIED RESERACH SYSTEMS ARS HOLDING N.V. (AN) | 2005-03-24 | — | — | WO | disclosed |