Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | PRCP | P42785 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32683479 | 1.00 | ADRA1D (0.35) | ADRA1DADRA1AADRA1BHDAC9TSHR | |
| SCHEMBL3659892 | 0.76 | HDAC9 (0.37) | HDAC9TSHRCA1CA2 | |
| SCHEMBL14659945 | 0.74 | ADRA1D (0.38) | ADRA1DADRA1AADRA1BHDAC9PRCP | |
| SCHEMBL8162156 | 0.71 | HDAC9 (0.39) | HDAC9TSHRCA1CA2 | |
| SCHEMBL9770120 | 0.70 | HDAC9 (0.41) | HDAC9TSHR | |
| SCHEMBL9770009 | 0.70 | HDAC9 (0.37) | ADRA1DADRA1AADRA1BHDAC9TSHR | |
| Hydrochloric Acid SCHEMBL9770018 | 0.69 | HDAC9 (0.40) | HDAC9TSHR | |
| SCHEMBL856816 | 0.69 | NOTUM (0.38) | HDAC9 | |
| SCHEMBL27817498 | 0.68 | ADRA1D (0.33) | ADRA1DADRA1AADRA1BPRCP | |
| SCHEMBL8061057 | 0.68 | HTR2A (0.39) | ADRA1DADRA1AADRA1BPRCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10336703-B2 | Process for the synthesis of ivacaftor and related compounds | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2019-07-02 | — | — | US | disclosed |
| US-20180127373-A1 | PROCESS FOR THE SYNTHESIS OF IVACAFTOR AND RELATED COMPOUNDS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2018-05-10 | — | — | US | disclosed |
| US-20180127373-A1 | PROCESS FOR THE SYNTHESIS OF IVACAFTOR AND RELATED COMPOUNDS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2018-05-10 | — | — | US | disclosed |
| US-8425784-B2 | Ozonolysis reactions in liquid CO2 and CO2-expanded solvents | UNIVERSITY OF KANSAS (US) | 2013-04-23 | — | — | US | disclosed |
| US-20090118498-A1 | OZONOLYSIS REACTIONS IN LIQUID CO2 AND CO2-EXPANDED SOLVENTS | ARCHER DANIELS MIDLAND COMPANY | 2009-05-07 | — | — | US | disclosed |
| US-7129263-B2 | Preparation of 3-azabicyclo [3.1.0] hexane derivatives | PFIZER INC. | 2006-10-31 | — | — | US | disclosed |
| EP-1675829-A1 | PREPARATION OF 3-AZABICYCLO [3.1.0] HEXANE DERIVATIVES | Pfizer Products Inc. (US) | 2006-07-05 | — | — | EP | disclosed |
| US-20050113437-A1 | Preparation of 3-azabicyclo [3.1.0] hexane derivatives | PFIZER INC. | 2005-05-26 | — | — | US | disclosed |
| WO-2005037790-A1 | PREPARATION OF 3-AZABICYCLO [3.1.0] HEXANE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2005-04-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10336703-B2 | Process for the synthesis of ivacaftor and related compounds | AVPR1A, ACVR1, AVPR2 | ADRA1D 6/4885ADRA1A 8/4885ADRA1B 24/4885 |
| US-20180127373-A1 | PROCESS FOR THE SYNTHESIS OF IVACAFTOR AND RELATED COMPOUNDS | AVPR1A, ACVR1, AVPR2 | ADRA1D 6/4885ADRA1A 8/4885ADRA1B 24/4885 |
| US-20050113437-A1 | Preparation of 3-azabicyclo [3.1.0] hexane derivatives | ADH1C, ADH1A, ADH5 | ADRA1D 86/4885ADRA1A 290/4885ADRA1B 218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.